Description

4-Bromo-2,5-Difluorophenylboronic Acid is a high-purity boronic acid derivative, a critical building block in modern synthetic chemistry. Its value lies in enabling precise carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone for constructing complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors, where it is used to develop novel active ingredients and functional organic molecules.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for fluorine-containing drug candidates targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Building block for creating novel herbicides, fungicides, and insecticides that leverage the unique properties of bromine and fluorine substituents for enhanced bioactivity and environmental stability.
• Material Science Research: Used in the development of organic electronic materials, such as OLED (Organic Light-Emitting Diode) emitters and charge transport materials, where the difluorophenyl core influences electronic properties.
• Ligand and Catalyst Development: Serves as a starting material for synthesizing specialized ligands used in asymmetric catalysis and transition metal complexes.
• Chemical Biology & Proteomics: Employed in the synthesis of molecular probes and activity-based protein profiling (ABPP) agents for studying enzyme function and drug discovery.
• Custom Synthesis & Contract Manufacturing: A vital reagent for custom synthesis houses and CROs (Contract Research Organizations) serving the global life sciences industry.

Basic Information

Product Name	4-Bromo-2,5-Difluorophenylboronic Acid
CAS No.	1106676-82-7
Molecular Formula	C6H4BBrF2O2
Molecular Weight	236.81 g/mol
Synonyms	(4-Bromo-2,5-difluorophenyl)boronic acid; 2,5-Difluoro-4-bromophenylboronic acid; B-(4-Bromo-2,5-difluorophenyl)boronic acid; 4-Bromo-2,5-difluorobenzeneboronic acid; Boronic acid, B-(4-bromo-2,5-difluorophenyl)-; 1106676-82-7; 4-Br-2,5-F2-PhB(OH)2
EINECS	Contact for details

Quality Control

Every batch of 4-Bromo-2,5-Difluorophenylboronic Acid is manufactured under strict quality management systems. We employ advanced analytical techniques including HPLC, NMR (¹H, ¹³C, ¹⁹F, ¹¹B), and GC-MS to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable performance in your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (argon or nitrogen) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Assay (NMR)	≥95.0%
Water Content (KF)	≤1.0%
Heavy Metals	<20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.