Description

5-Bromo-2-(Morpholino)Benzonitrile is a high-purity, advanced pharmaceutical intermediate featuring a benzonitrile core substituted with bromine and a morpholine ring. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of complex molecules with targeted biological activity. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of new active pharmaceutical ingredients (APIs), particularly for oncology and central nervous system (CNS) drug candidates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel small-molecule drug candidates, especially kinase inhibitors and receptor modulators.
• Agrochemical Research: Used in the development of new herbicides and pesticides, leveraging its halogenated aromatic structure.
• Material Science: Serves as a monomer or functional additive in the creation of specialty polymers and liquid crystals.
• Academic & Contract Research: Employed in chemical libraries for high-throughput screening (HTS) and structure-activity relationship (SAR) studies.
• Chemical Synthesis: Utilized in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) for constructing biaryl systems.

Basic Information

Product Name	5-Bromo-2-(Morpholino)Benzonitrile
CAS No.	1105665-08-4
Molecular Formula	C11H11BrN2O
Molecular Weight	267.12 g/mol
Synonyms	2-Morpholino-5-bromobenzonitrile; 5-Bromo-2-morpholinobenzonitrile; Benzonitrile, 5-bromo-2-(4-morpholinyl)-; 1105665-08-4; 5-Bromo-2-morpholin-4-ylbenzonitrile; 4-(5-Bromo-2-cyanophenyl)morpholine; 5-Bromo-2-(4-morpholinyl)benzonitrile
EINECS	Contact for details

Quality Control

Our 5-Bromo-2-(Morpholino)Benzonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply for critical research and development pipelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent degradation and moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.