Description

1-tert-Butyl 3-Ethyl 3-Carbamoylazetidine-1,3-Dicarboxylate is a high-purity, advanced pharmaceutical intermediate belonging to the azetidine class of heterocyclic compounds. This compound is of significant value for its role as a key building block in the synthesis of complex active pharmaceutical ingredients (APIs) and novel drug candidates. It is primarily sought after by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in medicinal chemistry and process development.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of target molecules for drug discovery programs, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Medicinal Chemistry Research: Serves as a versatile scaffold for constructing molecular libraries and exploring structure-activity relationships (SAR) due to its functionalized azetidine core.
• Process Chemistry & Scale-Up: Used in route scouting, optimization, and pilot-scale production of clinical trial materials, where consistent quality and reliable supply are paramount.
• API Synthesis: Incorporated into the final synthetic steps for producing candidate drugs that require the 3-carbamoylazetidine-1,3-dicarboxylate moiety.
• Custom Synthesis & Contract Manufacturing: Supplied to partners requiring bespoke, high-quality building blocks for proprietary synthesis projects under strict confidentiality agreements.

Basic Information

Product Name	1-tert-Butyl 3-Ethyl 3-Carbamoylazetidine-1,3-Dicarboxylate
CAS No.	1105663-94-2
Molecular Formula	C12H20N2O5
Molecular Weight	272.30 g/mol
Synonyms	1-(tert-Butyl) 3-ethyl 3-carbamoylazetidine-1,3-dicarboxylate; 3-Carbamoylazetidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester; Azetidine-1,3-dicarboxylic acid, 3-carbamoyl-, 1-(1,1-dimethylethyl) 3-ethyl ester; 1-Boc-3-ethyl 3-carbamoylazetidine-1,3-dicarboxylate; tert-Butyl ethyl 3-carbamoylazetidine-1,3-dicarboxylate; 3-(Ethoxycarbonyl)-3-carbamoylazetidine-1-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our 1-tert-Butyl 3-Ethyl 3-Carbamoylazetidine-1,3-Dicarboxylate is manufactured under a strict quality management system to ensure batch-to-batch consistency and high purity suitable for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to cGMP principles where applicable to support our clients' regulatory and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere if necessary to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.