Description

Dl-3-Bromo-n-[(9H-Fluoren-9-Ylmethoxy)Carbonyl]- Phenylalanine is a specialized, non-natural amino acid derivative featuring a bromine substituent and an Fmoc-protected amine group. This compound is a critical building block in modern solid-phase peptide synthesis (SPPS), enabling the precise incorporation of brominated phenylalanine residues into peptide chains. It is essential for researchers and manufacturers in pharmaceutical development, bioconjugation, and proteomics who require high-purity, structurally defined intermediates for creating novel peptide-based therapeutics and probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected intermediate for the automated synthesis of peptides containing bromo-phenylalanine, used in drug discovery and biochemical research.
• Pharmaceutical Intermediate: Serves as a precursor in the development of peptide-based active pharmaceutical ingredients (APIs) and investigational new drugs.
• Bioconjugation and Labeling: The bromine atom provides a handle for further functionalization via cross-coupling reactions (e.g., Suzuki, Sonogashira) to attach fluorescent tags, affinity labels, or other biomolecules.
• Structure-Activity Relationship (SAR) Studies: Used to synthesize peptide analogs to study the effect of halogenation on binding affinity, stability, and biological activity.
• Academic and Industrial R&D: A valuable reagent for research laboratories and CROs (Contract Research Organizations) focused on peptide chemistry and medicinal chemistry.
• Production of Non-Natural Amino Acids: Acts as a protected form of 3-bromo-phenylalanine for further chemical transformations and library synthesis.

Basic Information

Product Name	Dl-3-Bromo-n-[(9H-Fluoren-9-Ylmethoxy)Carbonyl]- Phenylalanine
CAS No.	1105045-66-6
Molecular Formula	C24H20BrNO4
Molecular Weight	466.33 g/mol
Synonyms	Fmoc-3-Bromo-DL-phenylalanine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-bromo-DL-phenylalanine; 3-Bromo-DL-phenylalanine, N-Fmoc derivative; Fmoc-DL-3-Br-Phe-OH; DL-3-Bromo-N-Fmoc-phenylalanine; N-α-Fmoc-3-bromo-DL-phenylalanine; (RS)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(3-bromophenyl)propanoic acid
EINECS	Contact for details

Quality Control

Our Dl-3-Bromo-n-[(9H-Fluoren-9-Ylmethoxy)Carbonyl]- Phenylalanine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and Mass Spectrometry. We provide comprehensive Certificates of Analysis (COA) detailing purity, assay, and impurity profiles to support your GMP and research documentation needs. Specifications can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay	95.0% - 102.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.