Description

Boc-6-Bromo-Dl-Tryptophan is a protected derivative of the essential amino acid tryptophan, featuring a tert-butoxycarbonyl (Boc) protecting group on the amine and a bromine substitution at the 6-position of the indole ring. This compound is a critical synthetic intermediate, enabling the controlled incorporation of modified tryptophan residues into peptide chains for advanced research and development. It is primarily utilized by pharmaceutical researchers, peptide chemists, and biotechnology companies engaged in the development of novel therapeutic peptides, peptidomimetics, and biochemical probes.

Application

• Pharmaceutical Research & Development: As a key building block for the solid-phase and solution-phase synthesis of novel peptide-based drug candidates and bioactive peptides.
• Peptidomimetic Design: Used to introduce brominated tryptophan analogs into peptide backbones to study structure-activity relationships (SAR), enhance metabolic stability, or modulate receptor binding affinity.
• Biochemical Probe Synthesis: Serves as a precursor for creating labeled or photoaffinity probes to study protein-protein interactions and enzyme mechanisms.
• Academic Research: Employed in chemical biology and medicinal chemistry laboratories for investigating peptide function and developing new synthetic methodologies.
• API Intermediate: Potential use in the multi-step synthesis of complex active pharmaceutical ingredients (APIs) that require modified amino acid architectures.

Basic Information

Product Name	Boc-6-Bromo-Dl-Tryptophan
CAS No.	1104606-57-6
Molecular Formula	C₁₆H₁₉BrN₂O₄
Molecular Weight	383.24 g/mol
Synonyms	N-α-Boc-6-bromo-DL-tryptophan; (RS)-2-[(tert-Butoxycarbonyl)amino]-3-(6-bromo-1H-indol-3-yl)propanoic acid; 6-Bromo-DL-tryptophan Boc derivative; Boc-6-Br-DL-Trp-OH; tert-Butyl (6-bromo-1H-indol-3-yl)methylcarbamate; 6-Bromotryptophan, N-Boc-protected; DL-6-Bromotryptophan N-Boc; BOC-DL-6-BROMOTRYPTOPHAN
EINECS	Contact for details

Quality Control

Our Boc-6-Bromo-Dl-Tryptophan is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity assessment, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results to ensure compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Loss on Drying	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.