Description

n-[3-(3-Dimethylaminoacryloyl)Phenyl]-n-Ethylacetamide-D5 is a deuterated derivative of a key intermediate used in advanced pharmaceutical research and development. This compound is specifically designed for use in mass spectrometry, metabolic studies, and as an internal standard for quantitative analysis, providing enhanced accuracy and reliability in analytical workflows. It is an essential material for research chemists, analytical scientists, and pharmaceutical developers working in drug discovery, pharmacokinetics, and bioanalytical method validation.

Application

• Primary use as a deuterated internal standard for the quantification of its non-deuterated counterpart via LC-MS/MS.
• Critical component in drug metabolism and pharmacokinetic (DMPK) studies for tracing and analyzing metabolite pathways.
• Utilized in bioanalytical method development and validation to ensure accuracy and precision.
• Research tool in pharmaceutical R&D for investigating the stability and degradation profiles of active pharmaceutical ingredients (APIs).
• Applied in isotope dilution mass spectrometry for high-precision quantitative analysis in complex biological matrices.
• Used in the synthesis of labeled compounds for mechanistic studies and reaction pathway elucidation.

Basic Information

Product Name	n-[3-(3-Dimethylaminoacryloyl)Phenyl]-n-Ethylacetamide-D5
CAS No.	1104483-92-2
Molecular Formula	C15H15D5N2O2
Molecular Weight	265.36 g/mol (for deuterated form)
Synonyms	N-Ethyl-N-[3-(3-dimethylaminoacryloyl)phenyl]acetamide-d5; 1-(3-((Ethyl-d5)amino)phenyl)-3-(dimethylamino)prop-2-en-1-one; Deuterated N-Ethyl Enaminone Intermediate; Acetamide, N-[3-[3-(dimethylamino)-1-oxo-2-propen-1-yl]phenyl]-N-(ethyl-d5)-; 1104483-92-2; Deuterated API Intermediate; D5-Labelled Enaminone Derivative
EINECS	Contact for details

Quality Control

Our deuterated compounds are produced under strict quality control protocols to ensure isotopic purity, chemical purity, and batch-to-batch consistency suitable for sensitive analytical applications. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and LC-MS. Certificates of Analysis (COA) detailing isotopic enrichment (D5), chemical purity, and identity are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D5, LC-MS)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.