Description

2-(Trifluoromethoxy)-L-Phenylalanine is a non-natural, fluorinated derivative of the essential amino acid L-phenylalanine, distinguished by the presence of a trifluoromethoxy substituent on the aromatic ring. This structural modification imparts unique physicochemical properties, making it a valuable chiral building block for advanced pharmaceutical and agrochemical research. It is primarily utilized by R&D chemists and process development scientists in the life sciences sector. The compound is supplied to meet the stringent purity requirements of modern drug discovery and development pipelines.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in oncology, neurology, and metabolic disease research.
• Peptidomimetics & PROTACs: Incorporation into peptide backbones and proteolysis-targeting chimeras (PROTACs) to enhance metabolic stability, membrane permeability, and binding affinity.
• Agrochemical Research: Serves as a precursor for developing new herbicides and pesticides with improved efficacy and environmental profiles.
• Fluorine Chemistry & Labeling: Used in 19F NMR studies and as a tracer molecule in metabolic pathway analysis due to the fluorine atoms.
• Ligand & Catalyst Development: Employed in the design of chiral ligands and organocatalysts for asymmetric synthesis.
• Academic & Institutional Research: Fundamental research tool in medicinal chemistry and chemical biology for structure-activity relationship (SAR) studies.

Basic Information

Product Name	2-(Trifluoromethoxy)-L-Phenylalanine
CAS No.	1103894-71-8
Molecular Formula	C10H10F3NO3
Molecular Weight	249.19 g/mol
Synonyms	(S)-2-Amino-3-[2-(trifluoromethoxy)phenyl]propanoic acid; L-2-(Trifluoromethoxy)phenylalanine; (S)-2-(Trifluoromethoxy)phenylalanine; 2-TFM-L-Phe; OCF3-L-Phenylalanine; 2-(Trifluoromethoxy)-L-Phe; F3CO-Phe-OH; 2-(Trifluoromethoxyl)-L-Phenylalanine
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for research and development. Each batch is characterized using advanced analytical techniques including HPLC, NMR, and MS to confirm identity, chiral purity, and chemical purity. Certificates of Analysis (COA) are available upon request, detailing all relevant specifications. We adhere to a quality management system to ensure batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.