Description

Generation 2 Thiol Reactive C6 Guanidine Functionalized Dendrimer is a precisely engineered, multifunctional nanomaterial designed for advanced bioconjugation and surface modification. Its core value lies in the high-density presentation of guanidine groups for strong cationic/binding interactions, combined with terminal thiol-reactive moieties for stable covalent linkage to biomolecules and surfaces. This product is essential for researchers and manufacturers in biomedical engineering, diagnostics, and advanced material science who require sophisticated platforms for drug delivery, biosensor development, and the creation of functional coatings.

Application

• Drug Delivery Systems: As a functional nanocarrier for the targeted delivery of nucleic acids (siRNA, DNA) and therapeutic proteins, leveraging the guanidine groups for enhanced cellular uptake.
• Biosensor & Diagnostic Platforms: Immobilization of antibodies, enzymes, or peptides onto sensor surfaces via thiol-gold or thiol-maleimide chemistry for enhanced sensitivity and stability.
• Gene Transfection & Transduction: Serving as a non-viral vector for gene therapy applications due to its ability to complex with genetic material and facilitate cell membrane penetration.
• Antimicrobial Coatings: Incorporation into coatings for medical devices or textiles, where the cationic guanidine functionality provides antimicrobial activity.
• Affinity Chromatography: Functionalization of resin beads for the purification of specific biomolecules through ionic or affinity interactions.
• Advanced Polymer & Composite Materials: Use as a cross-linking agent or multifunctional modifier to introduce specific chemical functionalities into polymer networks.
• Surface Patterning & Nano-fabrication: Creating precisely defined chemical patterns on gold, silicon, or other substrates for lab-on-a-chip and microfluidic devices.
• Bioconjugation Reagent: For the stable, site-specific coupling of peptides, proteins, or fluorescent dyes in probe and therapeutic agent development.

Basic Information

Product Name	Generation 2 Thiol Reactive C6 Guanidine Functionalized Dendrimer
CAS No.	1103518-95-1
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	G2 PAMAM Dendrimer, Guanidine-Terminated; C6-Thiol Reactive Guanidine Dendrimer; Generation 2 PAMAM-(NH-C(=NH)NH2)x, thiol-active; Poly(amidoamine) Dendrimer, G2, Guanidinylated; Thiol-Reactive Guanidine Dendrimer Nano-carrier; PAMAM-G2-Guanidine, Maleimide or Pyridyldithiol Functionalized; Multifunctional Guanidine Dendrimer; Amino-Terminated PAMAM Dendrimer, Guanidine Modified
EINECS	Contact for details

Quality Control

Every batch of our Generation 2 Thiol Reactive C6 Guanidine Functionalized Dendrimer undergoes rigorous analytical characterization to ensure consistent purity, functionality, and batch-to-batch reproducibility. Quality is verified through a suite of techniques including NMR, HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, degree of functionalization, and specific analytical data is provided with each shipment to support your research and quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive). Allow the sealed container to equilibrate to room temperature before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid or viscous solution
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Degree of Substitution (Guanidine)	Contact for details
Degree of Substitution (Thiol-Reactive Group)	Contact for details
Solvent Content (Residual)	≤ 2.0% (by GC or NMR)
Heavy Metals	≤ 10 ppm
Bacterial Endotoxins	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.