Description

Mpeg5-Propyne CAS NO 1101668-41-0 is a specialized functionalized polyethylene glycol derivative featuring a terminal alkyne group. This bifunctional structure is critical for enabling advanced bioconjugation and polymer chemistry through efficient click chemistry reactions, particularly copper-catalyzed azide-alkyne cycloaddition (CuAAC). It is an essential building block for researchers and manufacturers in the pharmaceutical and advanced materials sectors who require precise, reliable, and high-purity linkers for developing targeted drug delivery systems, diagnostic agents, and functional polymers.

Application

• Bioconjugation reagent for attaching drugs, dyes, or targeting ligands to antibodies, proteins, or peptides.
• Key intermediate in the synthesis of PEGylated prodrugs and biopharmaceuticals to enhance solubility and pharmacokinetics.
• Functional monomer or cross-linker for creating smart hydrogels and responsive polymer networks.
• Surface modification agent for nanoparticles and quantum dots to improve biocompatibility and enable further functionalization.
• Tool compound in chemical biology for labeling biomolecules via click chemistry for imaging and diagnostic applications.
• Building block for synthesizing complex dendrimers and branched polymer architectures.
• Intermediate in material science for developing non-fouling coatings and functional surfaces.

Basic Information

Product Name	Mpeg5-Propyne
CAS No.	1101668-41-0
Molecular Formula	CnH2n+2O6 (Contact for exact formula)
Molecular Weight	Contact for details
Synonyms	5kDa mPEG-Alkyne
Methoxy PEG5k Propyne
mPEG5000-Alkyne
α-Methoxy-ω-propynylpoly(ethylene glycol)
Poly(ethylene glycol) methyl ether propargyl ether (MW ~5000)
PEG-Alkyne (5kDa)
Click Chemistry PEG Reagent
EINECS	Contact for details

Quality Control

Our Mpeg5-Propyne is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity, precise molecular weight distribution, and functional group integrity. Certificates of Analysis (COA) detailing specifications for purity, endotoxin levels, and functional group substitution are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white waxy solid or powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Molecular Weight (SEC-MALS)	5000 ± 500 Da
Dispersity (Đ)	≤ 1.05
Alkyne Functionality	≥ 90%
Moisture Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.