Description

(11Br)-(+)-4,4-Di-T-Butyl-2,6-Bis[3,5-Bis(Trifluoromethyl)Phenyl]-4,5-Dihydro-3H-Dinaphtho[2,1-C:1',2'-E]Phosphepinium Bromide, 99% R-Maruoka Cat p-Tb is a high-purity, chiral phosphonium salt catalyst renowned for its exceptional performance in asymmetric synthesis. This compound is a key component of the Maruoka catalyst family, offering superior enantioselectivity and reactivity for critical carbon-carbon bond-forming reactions. It is an indispensable tool for R&D and production chemists in the pharmaceutical and fine chemical industries seeking to develop chiral active pharmaceutical ingredients (APIs) and advanced intermediates with high optical purity.

Application

• Asymmetric Phase-Transfer Catalysis (PTC): Enables highly enantioselective alkylation, Michael addition, and Mannich reactions under mild conditions.
• Pharmaceutical Intermediate Synthesis: Critical for the production of chiral drugs, including cardiovascular, neurological, and oncological therapeutics.
• Fine Chemical Manufacturing: Used in the synthesis of complex, high-value agrochemicals, flavors, and fragrances requiring precise stereochemical control.
• Academic & Industrial R&D: A benchmark catalyst for developing new asymmetric methodologies and optimizing synthetic routes in process chemistry.
• Scale-up Process Development: Suitable for transitioning from laboratory-scale discovery to pilot plant and commercial manufacturing due to its robustness.

Basic Information

Product Name	(11Br)-(+)-4,4-Di-T-Butyl-2,6-Bis[3,5-Bis(Trifluoromethyl)Phenyl]-4,5-Dihydro-3H-Dinaphtho[2,1-C:1',2'-E]Phosphepinium Bromide, 99% R-Maruoka Cat p-Tb
CAS No.	1101230-28-7
Molecular Formula	C55H36BrF12P
Molecular Weight	1043.73 g/mol
Synonyms	(+)-Maruoka Catalyst (p-tert-Butyl); (11bR)-4,4-Di-tert-butyl-2,6-bis[3,5-bis(trifluoromethyl)phenyl]-4,5-dihydro-3H-dinaphtho[2,1-c:1',2'-e]phosphepinium Bromide; R-Maruoka Catalyst; Maruoka's Chiral Quaternary Phosphonium Salt; (R)-4,4-Di-T-Butyl-2,6-Bis[3,5-Bis(Trifluoromethyl)Phenyl]-4,5-Dihydro-3H-Dinaphtho[2,1-C:1',2'-E]Phosphepinium Bromide; Asymmetric Phase Transfer Catalyst p-TB; Chiral Spiro-Type Phosphonium Salt Catalyst
EINECS	Contact for details

Quality Control

Every batch of our Maruoka Catalyst is manufactured and tested under strict quality management systems to ensure consistent, high-performance material for your critical asymmetric syntheses. We provide a comprehensive Certificate of Analysis (COA) with each shipment, detailing purity, enantiomeric excess, and key impurity profiles. Our quality protocols are designed to meet the stringent requirements of pharmaceutical development and cGMP environments, ensuring reliability and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed in a desiccated environment to maintain stability and catalytic activity. Use appropriate personal protective equipment and handle in a well-ventilated area.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 99.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.5% ee
Water Content (KF)	≤ 0.5% w/w
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.