Description

5-Trifluoromethylpyridine-2-Boronic Acid Pinacol Ester is a high-value organoboron building block crucial for modern synthetic chemistry. Its primary value lies in enabling efficient carbon-carbon bond formation via the Suzuki-Miyaura cross-coupling reaction, a cornerstone of pharmaceutical and agrochemical development. This compound is essential for researchers and process chemists in the life sciences, electronics, and advanced materials sectors who require reliable, high-purity intermediates for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs), especially those containing the trifluoromethylpyridine moiety, which is prized for its metabolic stability and lipophilicity.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the trifluoromethyl group enhances biological activity and environmental persistence.
• Material Science Research: Serves as a precursor for creating functionalized polymers, liquid crystals, and organic electronic materials (OLEDs, OFETs).
• Cross-Coupling Reactions: Specifically designed for palladium-catalyzed Suzuki-Miyaura cross-coupling to introduce the 5-trifluoromethylpyridin-2-yl fragment into target molecules.
• Chemical Biology & Medicinal Chemistry: Employed in the synthesis of molecular probes, diagnostic agents, and candidate compounds for drug discovery programs.
• Custom Synthesis & Contract Manufacturing: A critical reagent for fine chemical and CDMO (Contract Development and Manufacturing Organization) companies producing bespoke compounds for clients.

Basic Information

Item	Details
Product Name	5-Trifluoromethylpyridine-2-Boronic Acid Pinacol Ester
CAS No.	1101205-23-5
Molecular Formula	C₁₂H₁₅BF₃NO₂
Molecular Weight	273.06 g/mol
Synonyms	2-(5-Trifluoromethyl-2-pyridinyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 5-(Trifluoromethyl)pyridine-2-boronic acid pinacol ester; 2-(5-Trifluoromethylpyridin-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 5-Trifluoromethyl-2-pyridineboronic acid pinacol ester; 2-(5-Trifluoromethyl-2-pyridyl)-1,3,2-dioxaborolane, 4,4,5,5-tetramethyl-; Pinacol 5-(trifluoromethyl)pyridine-2-boronate
EINECS	Contact for details

Quality Control

Our 5-Trifluoromethylpyridine-2-Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our commitment to cGMP and ISO standards ensures consistent quality suitable for research and commercial-scale applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.