Description

4-(Trifluoromethylsulfonyl)Phenylacetic Acid is a high-value fluorinated aromatic building block characterized by its phenylacetic acid core and a strongly electron-withdrawing trifluoromethylsulfonyl substituent. This unique structure makes it a critical intermediate for synthesizing advanced materials and active pharmaceutical ingredients (APIs) where enhanced metabolic stability and lipophilicity are required. It is primarily sought after by R&D chemists and process development teams in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel compounds with targeted properties.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in areas requiring fluorinated motifs for improved bioavailability and metabolic resistance.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, where the trifluoromethylsulfonyl group can enhance biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and transition metal complexes.
• Material Science Research: Employed in the development of organic electronic materials, such as semiconductors or charge-transport layers, due to its electron-deficient aromatic system.
• Custom Synthesis and Contract Manufacturing: A vital starting material for fine chemical and CDMO (Contract Development and Manufacturing Organization) projects requiring bespoke fluorinated compounds.

Basic Information

Product Name	4-(Trifluoromethylsulfonyl)Phenylacetic Acid
CAS No.	1099597-82-6
Molecular Formula	C9H7F3O4S
Molecular Weight	268.21 g/mol
Synonyms	2-[4-(Trifluoromethylsulfonyl)phenyl]acetic acid; 4-(Trifluoromethanesulfonyl)phenylacetic Acid; α-(4-(Trifluoromethylsulfonyl)phenyl)acetic Acid; p-(Trifluoromethylsulfonyl)phenylacetic Acid; 4-(Trifluoromethylsulfonyl)benzeneacetic Acid; TFS-PAA; 1099597-82-6 (CAS)
EINECS	Contact for details

Quality Control

We maintain stringent quality control protocols for all our fluorinated intermediates. Production follows current Good Manufacturing Practice (cGMP) principles where applicable, and each batch is analyzed to ensure it meets precise customer specifications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment, ensuring full traceability and compliance with your project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.