Description

1-Bromo-2-(3,3,3-Trifluoropropyl)Benzene is a high-value, multi-functional aromatic building block designed for advanced chemical synthesis. Its core value lies in the strategic combination of a reactive bromine substituent and a fluorinated alkyl chain, enabling precise molecular modifications to enhance properties like lipophilicity, metabolic stability, and binding affinity. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries developing next-generation active ingredients and specialty materials.

Application

• Pharmaceutical Intermediate: A key synthon for introducing the 3,3,3-trifluoropropyl moiety into drug candidates, particularly in the development of kinase inhibitors, CNS-active compounds, and anti-inflammatory agents.
• Agrochemical Synthesis: Used in the creation of novel herbicides, fungicides, and pesticides where the fluorine atoms improve biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials, improving dielectric anisotropy and thermal stability.
• Polymer Modification: Employed to incorporate fluorine into polymer backbones or side chains, enhancing chemical resistance, lowering surface energy, and improving optical properties.
• Cross-Coupling Reactions: The aryl bromide functionality makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Heck, and Buchwald-Hartwig aminations for complex molecule assembly.
• Fluorine-Containing Fine Chemicals: A versatile starting material for synthesizing various fluorinated fine chemicals and specialty solvents used in high-tech applications.

Basic Information

Product Name	1-Bromo-2-(3,3,3-Trifluoropropyl)Benzene
CAS No.	1099597-58-6
Molecular Formula	C9H8BrF3
Molecular Weight	253.06 g/mol
Synonyms	2-Bromo-1-(3,3,3-trifluoropropyl)benzene; 1-Bromo-2-(3,3,3-trifluoropropyl)benzene; o-Bromo(3,3,3-trifluoropropyl)benzene; Benzene, 1-bromo-2-(3,3,3-trifluoropropyl)-; (2-Bromophenyl)(3,3,3-trifluoropropyl)methane; 3,3,3-Trifluoropropyl-2-bromobenzene
EINECS	Contact for details

Quality Control

Our production of 1-Bromo-2-(3,3,3-Trifluoropropyl)Benzene adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot is characterized by advanced analytical techniques including GC, HPLC, NMR, and MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment. We support cGMP compliance for pharmaceutical use and can tailor specifications to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in amber glass or opaque packaging during storage and handling.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Purity (HPLC)	≥ 96.0%
Water Content (KF)	≤ 0.5%
Density (at 20°C)	~1.55 g/cm³
Refractive Index (n20D)	~1.48

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.