Description

1-Fluoro-4-(2,2,2-trifluoroethyl)-2-(trifluoromethyl)benzene is a high-value, multi-fluorinated aromatic building block of significant interest in advanced chemical synthesis. Its unique structure, featuring both a trifluoroethyl and a trifluoromethyl substituent on a fluorinated benzene ring, makes it a critical intermediate for introducing lipophilicity and metabolic stability into target molecules. This compound is essential for R&D and production within the pharmaceutical and agrochemical sectors, where precise fluorination patterns are required to modulate the biological activity and physicochemical properties of new compounds.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the development of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the research and manufacture of advanced herbicides, fungicides, and insecticides, where fluorine atoms enhance bioavailability and environmental persistence.
• Liquid Crystal & OLED Materials: Acts as a fluorinated core component in the synthesis of specialty chemicals for electronic displays and organic light-emitting diodes, improving dielectric properties and stability.
• Advanced Polymer Chemistry: Employed as a monomer or modifier to create fluorinated polymers with enhanced chemical resistance, thermal stability, and low surface energy for coatings and specialty plastics.
• Positron Emission Tomography (PET) Tracer Development: The fluorine-18 isotope can be introduced via precursor routes for creating radiolabeled tracers used in medical imaging.
• Organic Synthesis & Catalysis Research: A valuable substrate in methodological studies for C-H functionalization, cross-coupling reactions, and the development of new fluorination methodologies.

Basic Information

Product Name	1-Fluoro-4-(2,2,2-trifluoroethyl)-2-(trifluoromethyl)benzene
CAS No.	1099597-38-2
Molecular Formula	C9H5F7
Molecular Weight	246.12 g/mol
Synonyms	2-(Trifluoromethyl)-1-fluoro-4-(2,2,2-trifluoroethyl)benzene; 4-(2,2,2-Trifluoroethyl)-2-(trifluoromethyl)fluorobenzene; 1-Fluoro-4-(2,2,2-trifluoroethyl)-α,α,α-trifluorotoluene; [2-(Trifluoromethyl)-4-fluorophenyl](trifluoro)ethane; Benzene, 1-fluoro-4-(2,2,2-trifluoroethyl)-2-(trifluoromethyl)-; FTB Trifluoroethyl Trifluoromethyl Fluorobenzene
EINECS	Contact for details

Quality Control

Our 1-Fluoro-4-(2,2,2-trifluoroethyl)-2-(trifluoromethyl)benzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our production adheres to cGMP principles where applicable, ensuring reliability for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.