Description

1-Bromo-4-Chloro-2-(2,2,2-Trifluoroethyl)Benzene is a high-value, multi-functional halogenated aromatic building block essential for advanced organic synthesis. Its unique structure, featuring bromine, chlorine, and a trifluoroethyl group, makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon in the development of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoroethyl moiety can enhance biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for sophisticated ligands in transition metal catalysis and organocatalysis, enabling novel asymmetric transformations.
• Material Science Research: Employed in the synthesis of specialty polymers, liquid crystals, and organic electronic materials due to its ability to modify solubility and electronic characteristics.
• Cross-Coupling Reactions: The bromine and chlorine atoms provide orthogonal reactivity for sequential Suzuki, Stille, and Buchwald-Hartwig amination cross-coupling reactions.
• Fluorine Chemistry: Acts as a valuable source of a benzylic trifluoroethyl group for introducing fluorine atoms into target molecules to modulate lipophilicity and metabolic stability.

Basic Information

Product Name	1-Bromo-4-Chloro-2-(2,2,2-Trifluoroethyl)Benzene
CAS No.	1099597-30-4
Molecular Formula	C8H5BrClF3
Molecular Weight	273.48 g/mol
Synonyms	2-Bromo-5-Chloro(2,2,2-trifluoroethyl)benzene; 4-Chloro-1-bromo-2-(2,2,2-trifluoroethyl)benzene; 1-Bromo-4-chloro-2-(trifluoroethyl)benzene; 2-(2,2,2-Trifluoroethyl)-4-chlorobromobenzene; Benzene, 1-bromo-4-chloro-2-(2,2,2-trifluoroethyl)-; 4-Chloro-2-(2,2,2-trifluoroethyl)bromobenzene
EINECS	Contact for details

Quality Control

Our 1-Bromo-4-Chloro-2-(2,2,2-Trifluoroethyl)Benzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports compliance with ISO, GMP, and REACH standards where applicable for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and incompatible organic solvents. For long-term storage, consider inert gas purging to maintain product integrity.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.