Description

1,2-Dichloro-4-(2,2,2-trifluoroethyl)benzene is a high-purity halogenated aromatic building block of significant importance in advanced organic synthesis. Its unique structure, featuring both chloro and trifluoroethyl substituents, makes it a critical intermediate for the development of complex molecules, particularly in the pharmaceutical and agrochemical sectors. This compound is essential for researchers and manufacturers seeking to introduce specific halogenated motifs to enhance the biological activity, metabolic stability, or physical properties of target compounds.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of active pharmaceutical ingredients (APIs), especially those targeting central nervous system (CNS) disorders, due to the lipophilicity and electronic effects imparted by the trifluoroethyl group.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the dichloro and trifluoroethyl functionalities contribute to pesticidal efficacy and environmental persistence profiles.
• Material Science Precursor: Serves as a monomer or functionalization agent in the development of specialty polymers, liquid crystals, and organic electronic materials requiring specific halogenated aromatic units.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Stille) to construct complex biaryl systems for drug discovery and material research.
• Fluorine Chemistry Research: A valuable compound for studying the influence of the CF3CH2- group on aromatic systems, aiding in the design of new fluorinated molecules with tailored properties.

Basic Information

Product Name	1,2-Dichloro-4-(2,2,2-trifluoroethyl)benzene
CAS No.	1099597-16-6
Molecular Formula	C8H5Cl2F3
Molecular Weight	229.03 g/mol
Synonyms	3,4-Dichloro-α,α,α-trifluoroethylbenzene; 1,2-Dichloro-4-(2,2,2-trifluoroethyl)benzene; 4-(2,2,2-Trifluoroethyl)-1,2-dichlorobenzene; 2,3-Dichlorobenzotrifluoroethane; (2,3-Dichlorophenyl)(trifluoro)ethane; 1-(2,3-Dichlorophenyl)-2,2,2-trifluoroethane
EINECS	Contact for details

Quality Control

Our 1,2-Dichloro-4-(2,2,2-trifluoroethyl)benzene is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes rigorous analytical testing, including chromatography (HPLC, GC) and spectroscopy (NMR, IR), to confirm identity and quantify purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong bases and oxidizing agents. Recommended long-term storage temperature is between 2°C and 8°C to maintain optimal stability. Keep container tightly sealed when not in use to prevent moisture absorption and potential degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.