Description

4-Chloro-2,5-Difluoroiodobenzene is a high-purity, multi-halogenated benzene derivative serving as a critical building block in advanced organic synthesis. This compound is valued for its unique reactivity profile, where the iodine atom facilitates efficient cross-coupling reactions, while the chlorine and fluorine substituents allow for precise downstream functionalization. It is primarily required by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex molecules, such as active pharmaceutical ingredients (APIs) and novel crop protection agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, particularly those requiring halogenated aromatic cores for bioactivity or further modification.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides where the difluoro and chloro groups contribute to stability and binding affinity.
• Material Science Research: Employed in the creation of specialty polymers, liquid crystals, and organic electronic materials due to its ability to introduce halogens for tuning electronic properties.
• Cross-Coupling Reactions: Serves as an excellent substrate for palladium-catalyzed reactions like Suzuki, Stille, and Negishi couplings, leveraging the reactive iodine substituent.
• Chemical Library Development: Utilized in medicinal chemistry for the parallel synthesis of diverse compound libraries to explore structure-activity relationships (SAR).
• Fluorinated Compound Manufacturing: Acts as a starting material for introducing fluorine atoms into target molecules, a common strategy to improve metabolic stability and membrane permeability.

Basic Information

Product Name	4-Chloro-2,5-Difluoroiodobenzene
CAS No.	1097871-23-2
Molecular Formula	C6H2ClF2I
Molecular Weight	274.44 g/mol
Synonyms	1-Chloro-4-iodo-2,5-difluorobenzene; 2,5-Difluoro-4-chloroiodobenzene; 4-Chloro-2,5-difluoro-1-iodobenzene; Benzene, 1-chloro-4-iodo-2,5-difluoro-; Iodobenzene, 4-chloro-2,5-difluoro-; (4-Chloro-2,5-difluorophenyl)iodide
EINECS	Contact for details

Quality Control

Our 4-Chloro-2,5-Difluoroiodobenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity assessment and NMR for structural confirmation, to ensure compliance with exacting R&D and pilot-scale production standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and consistency for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flames. Due to its light-sensitive nature, handling should be conducted under subdued lighting where practical.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.