Description

2-Propenamide, n-[(1R)-1-(1-Naphthalenyl)Ethyl]-3-[3-(Trifluoromethyl)Phenyl]-, (2E)- is a specialized chiral acrylamide derivative designed for advanced organic synthesis and pharmaceutical research. This compound is valued for its unique molecular architecture, which combines a naphthalene moiety with a trifluoromethylphenyl group, offering a versatile scaffold for constructing complex molecules. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications such as medicinal chemistry, asymmetric synthesis, and the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: Serves as a key chiral building block in the synthesis of potential drug candidates, particularly for central nervous system (CNS) and oncology targets.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its defined stereochemistry and functional group diversity.
• Asymmetric Catalysis Ligand Precursor: Acts as a precursor for synthesizing chiral ligands or organocatalysts used in enantioselective transformations.
• Agrochemical Development: Employed in the research and development of novel, high-performance crop protection agents with specific activity.
• Advanced Material Science: Investigated as a monomer or cross-linker for creating specialty polymers with tailored optical or electronic properties.
• Chemical Biology Probes: Utilized in the design of molecular probes for studying biological pathways and protein interactions.

Basic Information

Item	Details
Product Name	2-Propenamide, n-[(1R)-1-(1-Naphthalenyl)Ethyl]-3-[3-(Trifluoromethyl)Phenyl]-, (2E)-
CAS No.	1095393-66-0
Molecular Formula	C22H18F3NO
Molecular Weight	369.38 g/mol
Synonyms	(E)-N-[(1R)-1-(Naphthalen-1-yl)ethyl]-3-[3-(trifluoromethyl)phenyl]prop-2-enamide; (2E)-N-[(1R)-1-(1-Naphthyl)ethyl]-3-[3-(trifluoromethyl)phenyl]acrylamide; (R,E)-N-(1-(Naphthalen-1-yl)ethyl)-3-(3-(trifluoromethyl)phenyl)acrylamide; Chiral Acrylamide Derivative CAS 1095393-66-0; (E)-N-((R)-1-(1-Naphthyl)ethyl)cinnamamide derivative; 3-(3-(Trifluoromethyl)phenyl)-N-[(1R)-1-(1-naphthyl)ethyl]acrylamide
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch is characterized using advanced analytical techniques to confirm identity, purity, and enantiomeric excess. Certificates of Analysis (COA) detailing specific results for chiral purity, assay, and related substances are available upon request, supporting your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.