Description

5-(Trifluoromethyl)Isoxazole-4-Carboxylic Acid is a high-value fluorinated heterocyclic building block essential for modern synthetic chemistry. This compound matters as a key intermediate for introducing the metabolically stable and lipophilic trifluoromethyl group into complex molecules, significantly altering their biological activity and physicochemical properties. It is primarily needed by pharmaceutical and agrochemical R&D teams for the synthesis of novel active ingredients, including potential drugs and crop protection agents.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting kinases, enzymes, and GPCRs.
• Agrochemical Synthesis: Used in the research and development of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances bioactivity and environmental stability.
• Material Science Research: Serves as a precursor for creating specialty polymers, liquid crystals, or organic electronic materials with unique fluorinated properties.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes and tags for studying biological processes and target engagement.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis houses and CDMOs serving the life sciences industry.
• Academic & Institutional Research: Used in university and institutional labs for methodological development in organic synthesis and fluorine chemistry.

Basic Information

Product Name	5-(Trifluoromethyl)Isoxazole-4-Carboxylic Acid
CAS No.	1094702-34-7
Molecular Formula	C5H2F3NO3
Molecular Weight	181.07 g/mol
Synonyms	4-Isoxazolecarboxylic acid, 5-(trifluoromethyl)-; 5-(Trifluoromethyl)-4-isoxazolecarboxylic acid; 5-Trifluoromethylisoxazole-4-carboxylic acid; 1094702-34-7; 5-(Trifluoromethyl)isoxazole-4-carboxylic acid; 5-(Trifluoromethyl)-1,2-oxazole-4-carboxylic acid
EINECS	Contact for details

Quality Control

Our 5-(Trifluoromethyl)Isoxazole-4-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under anhydrous conditions to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.