Description

Carbamic Acid, n-[(2S)-2-Amino-3-[(3R)-Tetrahydro-2H-Pyran-3-Yl]Propyl]-n-Methyl-, 1,1-Dimethylethyl Ester is a sophisticated chiral building block featuring a protected amino acid scaffold and a tetrahydro-2H-pyran moiety. This compound is of significant value for its role in the synthesis of complex, biologically active molecules, particularly in pharmaceutical research and development. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries for constructing novel drug candidates, especially those targeting proteases or requiring specific stereochemical configurations.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for protease inhibitors and other small molecule therapeutics.
• Peptidomimetic Synthesis: Used to incorporate non-natural amino acid structures into peptide chains to enhance stability, bioavailability, and target specificity.
• Medicinal Chemistry Research: Serves as a versatile building block for constructing compound libraries in drug discovery programs to explore structure-activity relationships (SAR).
• Process Chemistry Development: Employed in scaling up synthetic routes for potential drug candidates from milligram to kilogram scale under GMP-like conditions.
• Bioconjugation & Probe Development: Can be utilized to create labeled compounds or probes for biochemical and pharmacological studies.

Basic Information

Item	Detail
Product Name	Carbamic Acid, n-[(2S)-2-Amino-3-[(3R)-Tetrahydro-2H-Pyran-3-Yl]Propyl]-n-Methyl-, 1,1-Dimethylethyl Ester
CAS No.	1093869-21-6
Molecular Formula	C15H30N2O3
Molecular Weight	286.41 g/mol
Synonyms	(2S)-2-[(tert-Butoxycarbonyl)(methyl)amino]-3-[(3R)-tetrahydro-2H-pyran-3-yl]propan-1-amine; tert-Butyl N-[(2S)-2-amino-3-[(3R)-oxan-3-yl]propyl]-N-methylcarbamate; Boc-N-Me-(R)-3-(3-pyranyl)-L-alaninamide; (S)-2-((tert-Butoxycarbonyl)(methyl)amino)-3-((R)-tetrahydro-2H-pyran-3-yl)propan-1-amine; N-Boc-N-methyl-L-3-((R)-tetrahydropyran-3-yl)alaninol; Chiral Boc-protected amino alcohol derivative.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality control protocols to ensure batch-to-batch consistency and high chemical purity, critical for sensitive pharmaceutical applications. Quality is verified through comprehensive analytical techniques including HPLC, GC, NMR, and chiral analysis. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment. We support development under quality agreements and can supply material suitable for use in GMP-regulated environments upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. For long-term storage, consider storing at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.