Description

4-Ethynyl-1H-Indazole is a high-value, functionalized heterocyclic building block of significant interest in advanced organic synthesis. Its core structure, featuring both an indazole scaffold and a terminal alkyne group, makes it a versatile precursor for constructing complex molecular architectures via click chemistry and cross-coupling reactions. This compound is primarily utilized by pharmaceutical and agrochemical research organizations for the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly for kinase inhibitors and other targeted therapies.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and plant growth regulators.
• Material Science: Serves as a building block for creating advanced polymers, ligands for catalysis, and organic electronic materials.
• Click Chemistry Substrate: The terminal alkyne group enables efficient Huisgen 1,3-dipolar cycloaddition reactions with azides for bioconjugation and polymer functionalization.
• Cross-Coupling Reactions: Acts as a coupling partner in Sonogashira, Suzuki-Miyaura, and other palladium-catalyzed reactions to create complex biaryl and conjugated systems.
• Chemical Biology Probe Development: Used to create tagged molecules for studying biological pathways and protein interactions.

Basic Information

Product Name	4-Ethynyl-1H-Indazole
CAS No.	1093847-83-6
Molecular Formula	C9H6N2
Molecular Weight	142.16 g/mol
Synonyms	4-Ethynyl-1H-indazole; 1H-Indazole, 4-ethynyl-; 4-Ethynylindazole; 4-Ethynyl-1H-indazole; 4-Ethynyl-1H-indazole (CAS 1093847-83-6); 4-Ethynylindazole, 1H-Indazole-4-ethyne
EINECS	Contact for details

Quality Control

Our 4-Ethynyl-1H-Indazole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	Off-white to light yellow powder or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.