Description

6,6-Difluorobicyclo[3.1.0]Hexane-3-Carboxylic Acid is a high-value, multifunctional fluorinated bicyclic building block essential for advanced organic synthesis. This compound matters for its unique strained ring structure and fluorine atoms, which are critical for modulating the physicochemical properties of target molecules, such as metabolic stability, lipophilicity, and bioavailability. It is primarily needed by pharmaceutical and agrochemical R&D teams for the development of novel active ingredients, including protease inhibitors and other small-molecule therapeutics.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of complex drug candidates, particularly those targeting viral proteases and neurological disorders.
• Agrochemical Research: Used to create novel herbicides and pesticides with enhanced activity and environmental profile.
• Material Science: Serves as a precursor for specialty polymers and advanced materials with unique fluorinated properties.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies and lead optimization to improve drug-like properties.
• Chemical Biology: Utilized as a probe or labeling agent due to the distinctive properties imparted by the difluorinated bicyclic scaffold.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects requiring sophisticated fluorinated architectures.

Basic Information

Product Name	6,6-Difluorobicyclo[3.1.0]Hexane-3-Carboxylic Acid
CAS No.	1093751-02-0
Molecular Formula	C8H8F2O2
Molecular Weight	174.15 g/mol
Synonyms	6,6-Difluoro-3-bicyclo[3.1.0]hexanecarboxylic Acid; 3-Bicyclo[3.1.0]hexanecarboxylic acid, 6,6-difluoro-; 6,6-Difluorobicyclo[3.1.0]hexane-3-carboxylic acid; Difluorinated Bicyclo[3.1.0]hexane Carboxylic Acid; 6,6-Difluoro-3-carboxybicyclo[3.1.0]hexane; Bicyclo[3.1.0]hexane-3-carboxylic acid, 6,6-difluoro-; 1093751-02-0
EINECS	Contact for details

Quality Control

Our 6,6-Difluorobicyclo[3.1.0]Hexane-3-Carboxylic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and batch-to-batch consistency suitable for research and scale-up. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.