Description

Eszopiclone-D8 is a deuterated analog of the non-benzodiazepine sedative-hypnotic Eszopiclone, specifically designed for use as an internal standard in analytical chemistry. This high-purity, isotopically labeled compound is essential for ensuring the accuracy and reliability of quantitative analyses, particularly in pharmacokinetic and bioequivalence studies. It is a critical material for pharmaceutical R&D laboratories, contract research organizations (CROs), and regulatory testing facilities that require precise measurement of Eszopiclone in complex biological matrices.

Application

• Internal Standard for LC-MS/MS: Primary application as a stable, isotopically labeled internal standard for the quantitative analysis of Eszopiclone in biological samples (plasma, serum, urine) using liquid chromatography-tandem mass spectrometry (LC-MS/MS).
• Pharmacokinetic & Metabolism Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) in clinical and pre-clinical research.
• Bioanalytical Method Development & Validation: Used to develop, optimize, and validate robust analytical methods compliant with FDA, EMA, and ICH guidelines.
• Forensic & Toxicology Analysis: Supports precise quantification in forensic toxicology for drug monitoring and compliance testing.
• Pharmaceutical Quality Control: Can be utilized in impurity profiling and stability-indicating assay methods for drug substance and product testing.
• Reference Material for Certified Standards: Serves as a key component in the preparation of certified reference materials (CRMs) for analytical laboratories.

Basic Information

Product Name	Eszopiclone-D8
CAS No.	1093385-24-0
Molecular Formula	C17H9D8ClN6O3
Molecular Weight	397.85 g/mol
Synonyms	(+)-Eszopiclone-D8; (S)-Zopiclone-D8; (S)-Zopiclone-d8; LUNESTA-D8; (5S)-6-(5-Chloro-2-pyridinyl)-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-yl 4-methyl-1-piperazinecarboxylate-d8; Deuterated Eszopiclone; Eszopiclone (Deuterated); Eszopiclone-d8 Internal Standard
EINECS	Contact for details

Quality Control

Our Eszopiclone-D8 is manufactured under strict quality control protocols to ensure the highest isotopic purity and chemical integrity required for sensitive analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing results for isotopic purity, chemical purity, and identity confirmation via advanced spectroscopic techniques. We support compliance with cGMP and relevant ICH guidelines for the preparation of reference standards.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Chemical Purity (HPLC)	≥ 99.0%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.