Description

2,2-Difluoro-2-(Quinolin-6-Yl)Acetic Acid is a high-value fluorinated quinoline derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring both a quinoline heterocycle and a difluoroacetic acid moiety, makes it indispensable for creating novel compounds with tailored properties. This intermediate is primarily sought by research and development teams in the pharmaceutical and agrochemical sectors for drug discovery and the development of new active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new active pharmaceutical ingredients (APIs), particularly in oncology and antiviral therapeutic areas.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and insecticides, leveraging the bioactivity of the quinoline scaffold.
• Material Science Precursor: Employed in the development of specialty chemicals, including ligands for catalysis and monomers for advanced polymers.
• Fluorine Chemistry Building Block: Essential for introducing the difluoromethylenecarboxyl group into target molecules to modulate their metabolic stability, lipophilicity, and bioavailability.
• Academic & Contract Research: Serves as a valuable reagent for methodological studies and the exploration of new fluorination reactions in university and CRO laboratories.

Basic Information

Product Name	2,2-Difluoro-2-(Quinolin-6-Yl)Acetic Acid
CAS No.	1093341-40-2
Molecular Formula	C₁₁H₇F₂NO₂
Molecular Weight	223.18 g/mol
Synonyms	2,2-Difluoro-2-(6-quinolyl)acetic acid; 2-(6-Quinolinyl)-2,2-difluoroacetic Acid; 6-Quinolyl-2,2-difluoroacetic Acid; 2,2-Difluoro-2-(quinolin-6-yl)ethanoic acid; (6-Quinolinyl)difluoroacetic Acid; DFQA; 1093341-40-2 (CAS)
EINECS	Contact for details

Quality Control

We maintain stringent quality control protocols for all our fine chemical intermediates. Production of 2,2-Difluoro-2-(Quinolin-6-Yl)Acetic Acid is monitored through in-process controls and finalized with comprehensive analytical testing to ensure batch-to-batch consistency and high purity. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, identity, and impurity profiles as verified by HPLC, NMR, and MS.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.