Description

Fluticasone Propionate-D5 is a deuterated analog of the potent synthetic corticosteroid fluticasone propionate, where five hydrogen atoms are replaced with deuterium. This stable isotope-labeled compound is an essential internal standard for the precise quantification of fluticasone propionate in complex biological matrices using advanced analytical techniques. It is a critical tool for pharmaceutical R&D and quality control laboratories focused on drug metabolism, pharmacokinetic studies, and bioanalytical method development.

Application

• Primary use as an internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS) and Gas Chromatography-Mass Spectrometry (GC-MS) for the accurate quantification of fluticasone propionate.
• Bioanalytical method development and validation for pharmacokinetic (PK) and pharmacodynamic (PD) studies in clinical and preclinical research.
• Metabolite identification and drug metabolism studies to understand the biotransformation pathways of fluticasone propionate.
• Quality control and assurance testing in pharmaceutical manufacturing to ensure batch consistency and purity of the active pharmaceutical ingredient (API).
• Use in environmental and forensic analysis for the detection and measurement of steroid compounds.
• Supporting regulatory submissions to agencies like the FDA and EMA by providing validated analytical data.

Basic Information

Item	Detail
Product Name	Fluticasone Propionate-D5
CAS No.	1093258-28-6
Molecular Formula	C25H26D5F3O5S
Molecular Weight	505.58 g/mol
Synonyms	Fluticasone-d5 Propionate; (6α,11β,16α,17α)-6,9-Difluoro-11-hydroxy-16-methyl-3-oxo-17-(1-oxopropoxy)androsta-1,4-diene-17-carbothioic acid S-(fluoromethyl) ester-d5; Fluticasone Propionate (D5); Fluticasone Propionate-d5; Deuterated Fluticasone Propionate; Fluticasone-D5 Propionate; Fluticasone Propionate Internal Standard
EINECS	Contact for details

Quality Control

Our Fluticasone Propionate-D5 is produced under strict quality management systems. Each batch is characterized and tested to ensure high chemical purity and isotopic enrichment, meeting the stringent requirements for use as a certified reference material in analytical laboratories. A comprehensive Certificate of Analysis (COA) detailing results for assay, isotopic purity, and related substances is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, typically between 15-25°C (59-77°F). Keep the container in a dry, cool, and well-ventilated area. For long-term storage, consider storing at -20°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98.0 atom % D
Chemical Purity	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.