Description

n-[(1S)-2'-Amino-3,3'-Dibromo-4,4',6,6'-Tetrakis(trifluoromethyl)[1,1'-biphenyl]-2-yl]-P,p-diphenyl-phosphinous amide is a sophisticated, high-value organophosphorus compound featuring a chiral, polyhalogenated biphenyl core. This molecule is of significant interest for its potential as a specialized ligand or catalyst precursor in advanced synthetic chemistry, particularly in asymmetric transformations. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the development of novel active ingredients and complex molecular architectures.

Application

• Asymmetric Catalysis: Serves as a precursor for chiral phosphine-based ligands used in transition metal catalysis for enantioselective synthesis.
• Pharmaceutical Intermediate: A key building block in the research and development of novel drug candidates, especially those requiring complex halogenated and fluorinated motifs.
• Advanced Material Research: Investigated for incorporation into specialty polymers or organic electronic materials due to its unique steric and electronic properties.
• Agrochemical Synthesis: Potential intermediate in the creation of high-performance, targeted agrochemicals.
• Methodology Development: Used by academic and industrial chemists to develop new synthetic methodologies involving challenging C–X bond formations.
• Ligand Library Screening: A valuable component in high-throughput screening for discovering new catalytic systems in cross-coupling and other metal-mediated reactions.

Basic Information

Product Name	n-[(1S)-2'-Amino-3,3'-Dibromo-4,4',6,6'-Tetrakis(trifluoromethyl)[1,1'-biphenyl]-2-yl]-P,p-diphenyl-phosphinous amide
CAS No.	1093238-03-9
Molecular Formula	C32H17Br2F12N2P
Molecular Weight	904.27 g/mol
Synonyms	(S)-N-(2'-Amino-3,3'-dibromo-4,4',6,6'-tetrakis(trifluoromethyl)-[1,1'-biphenyl]-2-yl)-P,P-diphenylphosphinous amide; (1S)-N-[2'-Amino-3,3'-dibromo-4,4',6,6'-tetrakis(trifluoromethyl)biphenyl-2-yl]-P,P-diphenylphosphinous amide; P,P-Diphenyl-N-[(1S)-3,3'-dibromo-4,4',6,6'-tetrakis(trifluoromethyl)[1,1'-biphenyl]-2'-amino-2-yl]phosphinous amide; Chiral Dibromotetrakis(trifluoromethyl)biphenyl Phosphinous Amide Derivative
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality protocols to ensure batch-to-batch consistency and high purity for research applications. Identity and purity are confirmed via a suite of analytical techniques including HPLC, NMR, and chiral analysis. A comprehensive Certificate of Analysis (COA) detailing purity, chiral purity (enantiomeric excess), and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry, and well-ventilated place. This compound is light-sensitive and easily oxidized; prolonged exposure to air or light should be avoided.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% e.e.
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.