Description

3-(Acetylamino)-n-Fmoc-Dl-Alanine is a protected amino acid derivative designed for advanced peptide synthesis. This compound matters for its role as a key building block in solid-phase peptide synthesis (SPPS), where the Fmoc group provides orthogonal protection. Pharmaceutical researchers and fine chemical manufacturers need it for the development of novel peptide-based therapeutics, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a critical Fmoc-protected amino acid for the automated, stepwise construction of complex peptides.
• Pharmaceutical Intermediate: For the research and development of peptide drugs targeting metabolic disorders, oncology, and infectious diseases.
• Bioconjugation: Serving as a modified amino acid precursor for creating peptide-protein or peptide-small molecule conjugates.
• Combinatorial Chemistry: Used in libraries for high-throughput screening to identify bioactive peptide leads.
• Biochemical Research: Employed in studying enzyme-substrate interactions, receptor binding, and signal transduction pathways.
• Antibody-Drug Conjugate (ADC) Development: As a component in the synthesis of peptide linkers for targeted drug delivery systems.

Basic Information

Product Name	3-(Acetylamino)-n-Fmoc-Dl-Alanine
CAS No.	1093189-52-6
Molecular Formula	C21H22N2O5
Molecular Weight	382.41 g/mol
Synonyms	Fmoc-DL-3-(Acetylamino)alanine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-(acetylamino)-DL-alanine; 3-Acetamido-N-[(9H-fluoren-9-ylmethoxy)carbonyl]alanine; Nα-Fmoc-Nβ-Acetyl-DL-diaminopropionic acid; Fmoc-3-Acetamido-DL-Ala-OH; N-Fmoc-3-(acetylamino)alanine; DL-3-(Acetylamino)-N-(9-fluorenylmethoxycarbonyl)alanine
EINECS	Contact for details

Quality Control

Our 3-(Acetylamino)-n-Fmoc-Dl-Alanine is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and chiral analysis to verify the DL-mixture. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific customer or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.