Description

[1-(tert-Butyl-Dimethyl-Silanyl)-5-Fluoro-1H-Indol-4-Yl]Boronic Acid is a high-value, organoboron building block featuring a protected indole core. This compound is essential for modern synthetic chemistry, particularly in cross-coupling reactions like the Suzuki-Miyaura reaction, enabling the precise construction of complex molecular architectures. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers for the development of novel active pharmaceutical ingredients (APIs) and advanced organic materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of fluorinated indole-based drug candidates, including potential kinase inhibitors and CNS-active compounds.
• Suzuki-Miyaura Cross-Coupling: Serves as a critical boronic acid partner for introducing the substituted indole moiety into biaryl and heterobiaryl systems under palladium catalysis.
• Medicinal Chemistry Research: Used in library synthesis for structure-activity relationship (SAR) studies and lead optimization programs.
• Agrochemical Development: Employed in creating novel fluorinated organic molecules with potential herbicidal or insecticidal activity.
• Material Science: A building block for organic electronic materials, such as those used in OLEDs, where the indole and fluorine units can tune electronic properties.
• Process Chemistry & Scale-up: Supplied for route scouting and pilot-scale production of target molecules in GMP and non-GMP environments.

Basic Information

Product Name	[1-(tert-Butyl-Dimethyl-Silanyl)-5-Fluoro-1H-Indol-4-Yl]Boronic Acid
CAS No.	1093066-72-8
Molecular Formula	C₁₄H₂₁BFNO₂Si
Molecular Weight	293.22 g/mol
Synonyms	4-Borono-5-fluoro-1-[(1,1-dimethylethyl)dimethylsilyl]-1H-indole; 5-Fluoro-1-[(tert-butyldimethylsilyl)]-1H-indol-4-ylboronic acid; 1-(Tert-Butyl-Dimethyl-Silanyl)-5-Fluoro-1H-Indole-4-Boronic Acid; 1-(TBDMS)-5-Fluoro-1H-indol-4-ylboronic acid; 4-Borono-5-fluoro-1-(tert-butyldimethylsilyl)-1H-indole; 5-Fluoro-1-[(1,1-dimethylethyl)dimethylsilyl]-1H-indole-4-boronic acid; B-[5-Fluoro-1-[(1,1-dimethylethyl)dimethylsilyl]-1H-indol-4-yl]boronic acid
EINECS	Contact for details

Quality Control

Our [1-(tert-Butyl-Dimethyl-Silanyl)-5-Fluoro-1H-Indol-4-Yl]Boronic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and batch-to-batch consistency suitable for demanding research and development applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its moisture-sensitive and light-sensitive nature. Allow the container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥95% (Area %)
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.