Description

Imatinib-D8 is a deuterated analog of the well-known tyrosine kinase inhibitor, Imatinib, specifically labeled with eight deuterium atoms. This stable isotope-labeled compound is essential for use as an internal standard in quantitative bioanalytical methods, ensuring unparalleled accuracy and reliability in pharmacokinetic and metabolic studies. It is a critical tool for pharmaceutical researchers, contract research organizations (CROs), and analytical laboratories engaged in drug development and therapeutic drug monitoring for oncology treatments.

Application

• Internal Standard for LC-MS/MS: Serves as a critical internal standard in Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) for the precise quantification of Imatinib in biological matrices like plasma, serum, and tissue homogenates.
• Pharmacokinetic (PK) Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) profiles in preclinical and clinical research.
• Metabolite Identification: Used in mass spectrometry to differentiate drug-derived metabolites from endogenous compounds, aiding in metabolic pathway elucidation.
• Bioequivalence Studies: Provides high-fidelity data for comparing the bioavailability of generic and innovator drug formulations.
• Therapeutic Drug Monitoring (TDM): Supports the development and validation of robust assays to monitor drug concentrations in patient samples for personalized oncology treatment.
• Drug Metabolism and Pharmacokinetics (DMPK) Research: A fundamental reagent in DMPK laboratories for investigating the in-vitro and in-vivo stability of Imatinib.

Basic Information

Item	Detail
Product Name	Imatinib-D8
CAS No.	1092942-82-9
Molecular Formula	C29H23D8N7O
Molecular Weight	494.64 g/mol
Synonyms	Imatinib-d8; STI571-d8; Gleevec-d8; Glivec-d8; 4-[(4-Methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino-d5]phenyl-d3]benzamide; CGP 57148B-d8; Deuterated Imatinib
EINECS	Contact for details

Quality Control

Every batch of Imatinib-D8 is manufactured and analyzed under strict quality management systems. We guarantee high chemical and isotopic purity, supported by comprehensive analytical data including NMR (¹H, ¹³C) and mass spectrometry. A Certificate of Analysis (COA) detailing purity, isotopic enrichment, and solvent content is provided with each shipment, ensuring compliance with the rigorous standards required for analytical and research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C or as recommended on the CoA. This product is hygroscopic (moisture-sensitive) and should be kept in a cool, dry place. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity	≥ 98.0 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.