Description

3(S)-Hydroperoxy Simvastatin is a key synthetic intermediate and oxidative metabolite of the widely prescribed cholesterol-lowering drug, Simvastatin. This compound is of significant value in pharmaceutical research and development, particularly for studying metabolic pathways and synthesizing novel active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical manufacturers, contract research organizations (CROs), and academic institutions engaged in advanced drug development and analytical method validation.

Application

• Pharmaceutical Intermediate: Critical precursor in the synthesis and scale-up of Simvastatin and related HMG-CoA reductase inhibitors.
• Metabolite Reference Standard: Used as an analytical standard in bioanalytical studies to identify and quantify oxidative metabolites in pharmacokinetic and pharmacodynamic research.
• Process Chemistry & Impurity Profiling: Essential for understanding and controlling oxidative degradation pathways during API manufacturing and stability studies.
• Drug Discovery Research: Serves as a building block for creating new chemical entities and analogs for structure-activity relationship (SAR) studies.
• Quality Control Laboratories: Employed in HPLC, LC-MS, and other chromatographic methods for system suitability and method validation.

Basic Information

Product Name	3(S)-Hydroperoxy Simvastatin
CAS No.	1092716-44-3
Molecular Formula	C25H38O7
Molecular Weight	450.57 g/mol
Synonyms	Simvastatin 3(S)-Hydroperoxide; 3(S)-Hydroperoxy Simvastatin; Simvastatin Hydroperoxide; (3S,7S,8S,8aR)-8-[2-[(2R,4R)-4-Hydroxy-6-oxo-3,4,5,6-tetrahydro-2H-pyran-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (2S)-2-methylbutanoate 3(S)-hydroperoxide; 3β-Hydroperoxy Simvastatin
EINECS	Contact for details

Quality Control

Our 3(S)-Hydroperoxy Simvastatin is manufactured under strict quality management systems. Each batch is characterized and tested using advanced analytical techniques including HPLC, NMR, and MS to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., nitrogen or argon) to minimize oxidation and degradation. Allow the sealed container to reach room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Assay	≥ 97.0%
Related Substances (HPLC)	Individual impurity ≤ 1.0%
Total Impurities	≤ 3.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.