Description

3(R)-Hydroperoxy Simvastatin is a key synthetic intermediate and oxidative metabolite of the widely prescribed cholesterol-lowering drug, Simvastatin. This compound is of significant importance in pharmaceutical research and development, particularly for studying metabolic pathways, pharmacokinetics, and for the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical manufacturers, contract research organizations (CROs), and academic institutions engaged in advanced drug discovery, process chemistry, and analytical method development.

Application

• Pharmaceutical Intermediate: Critical precursor in the synthesis and scale-up of Simvastatin and related HMG-CoA reductase inhibitors.
• Metabolite Reference Standard: Used as an analytical standard in bioanalytical studies to identify and quantify oxidative metabolites in pharmacokinetic and ADME (Absorption, Distribution, Metabolism, and Excretion) research.
• Process Chemistry & Impurity Profiling: Essential for identifying, characterizing, and controlling process-related impurities during API manufacturing to ensure final product purity and regulatory compliance.
• Drug Discovery Research: Serves as a building block for the design and synthesis of new chemical entities with potential therapeutic activity for cardiovascular diseases.
• Analytical Method Development: Used to develop and validate stability-indicating HPLC/UPLC methods for Simvastatin and its related substances.
• Stability Studies: Employed in forced degradation studies to understand the degradation pathways of Simvastatin under various stress conditions (e.g., oxidative stress).

Basic Information

Product Name	3(R)-Hydroperoxy Simvastatin
CAS No.	1092716-42-1
Molecular Formula	C25H38O7
Molecular Weight	450.57 g/mol
Synonyms	Simvastatin 3(R)-Hydroperoxide; 3(R)-Hydroperoxy Simvastatin; Simvastatin Hydroperoxide; (3R)-3-Hydroperoxy-2,2-dimethylbutanoic Acid (1S,7S,8S,8aR)-1,2,3,7,8,8a-Hexahydro-7-methyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl Ester; 3β-Hydroperoxy Simvastatin; Simvastatin 3β-Hydroperoxide; 1092716-42-1
EINECS	Contact for details

Quality Control

Our 3(R)-Hydroperoxy Simvastatin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, supporting regulatory filings and internal quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., nitrogen or argon) to minimize degradation due to its sensitivity to oxidation and light. Allow the container to reach room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.