Description

Deuterated Atazanivir-D3-3 is a stable isotope-labeled analog of the antiretroviral drug Atazanavir, specifically deuterated at three positions. This compound is an essential internal standard for the precise quantification of Atazanavir in complex biological matrices using advanced analytical techniques like LC-MS/MS. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities engaged in drug metabolism, pharmacokinetic (DMPK) studies, and bioanalytical method development.

Application

• Primary use as an internal standard for the accurate quantification of Atazanavir in bioanalytical assays.
• Critical for drug metabolism and pharmacokinetic (DMPK) studies to understand the absorption, distribution, metabolism, and excretion of Atazanavir.
• Enhances the reliability of data in clinical trial sample analysis and therapeutic drug monitoring (TDM).
• Used in the development and validation of robust LC-MS/MS methods for anti-retroviral drug analysis.
• Supports pharmaceutical quality control and impurity profiling of Atazanavir drug substances and products.
• Facilitates research into drug-drug interactions and metabolic stability of Atazanavir.

Basic Information

Product Name	Deuterated Atazanivir-D3-3
CAS No.	1092540-52-7
Molecular Formula	C38H49D3N6O7
Molecular Weight	~ 707.9 g/mol
Synonyms	Atazanavir-d3; Deuterated Atazanavir; Atazanavir Internal Standard; BMS-232632-d3; (3S,8S,9S,12S)-3,12-Bis(1,1-dimethylethyl)-8-hydroxy-4,11-dioxo-9-(phenylmethyl)-6-[[4-(2-pyridinyl)phenyl]methyl]-2,5,6,10,13-pentaazatetradecanedioic Acid dimethyl Ester-d3; [D3]-Atazanavir
EINECS	Contact for details

Quality Control

Our Deuterated Atazanivir-D3-3 is manufactured under strict quality systems to ensure the high chemical purity and isotopic enrichment required for sensitive analytical applications. Each batch is characterized by NMR, LC-MS, and HPLC to confirm identity, chemical purity, and deuterium incorporation. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to expected mass
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Incorporation)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.