Description

Deuterated Atazanivir-D3-2 is a stable isotope-labeled analog of the antiretroviral drug Atazanavir, where specific hydrogen atoms are replaced with deuterium (D). This compound is a critical internal standard used in quantitative bioanalytical methods, ensuring the highest accuracy and reliability in pharmacokinetic and metabolic studies. It is an essential tool for pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers focused on drug development and regulatory compliance for HIV therapies.

Application

• Quantitative Bioanalysis: Serves as a stable isotope-labeled internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS/MS) for the precise quantification of Atazanavir in biological matrices (plasma, serum).
• Pharmacokinetic (PK) Studies: Enables accurate measurement of drug absorption, distribution, metabolism, and excretion (ADME) profiles in clinical and non-clinical studies.
• Metabolite Identification & Profiling: Aids in distinguishing drug-derived metabolites from endogenous compounds in complex biological samples.
• Method Development & Validation: Critical for developing and validating robust, GLP/GCP-compliant analytical methods for regulatory submissions.
• Drug-Drug Interaction Studies: Used in assays to investigate potential interactions between Atazanavir and other co-administered medications.
• Quality Control in Manufacturing: Can be utilized in analytical procedures for quality control of the active pharmaceutical ingredient (API).

Basic Information

Product Name	Deuterated Atazanivir-D3-2
CAS No.	1092540-51-6
Molecular Formula	C38H49D3N6O7
Molecular Weight	~ 707.9 g/mol
Synonyms	Atazanavir-d3; Deuterated Atazanavir; Atazanavir (D3 labeled); (3S,8S,9S,12S)-3,12-Bis(1,1-dimethylethyl)-8-hydroxy-4,11-dioxo-9-(phenylmethyl)-6-[[4-(2-pyridinyl)phenyl]methyl]-2,5,6,10,13-pentaazatetradecanedioic Acid Dimethyl Ester-d3; BMS-232632-d3; Reyataz-d3 (labeled analog)
EINECS	Contact for details

Quality Control

Our Deuterated Atazanivir-D3-2 is manufactured under strict quality systems to ensure it meets the exacting standards required for analytical reference materials. Each batch undergoes comprehensive testing, including determination of isotopic purity (deuterium incorporation), chemical purity, and confirmation of structure. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting results for HPLC purity, NMR, and mass spectrometry to guarantee consistency and reliability for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. Keep the container in a dry, cool, and well-ventilated place.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98.0 atom % D
Chemical Purity (NMR)	≥ 95.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.