Description

5-Chloro-2-Fluoroanisole is a high-purity fluorinated and chlorinated anisole derivative, serving as a critical advanced intermediate in modern organic synthesis. Its unique halogenated aromatic structure makes it an essential building block for constructing complex molecules with tailored properties. This compound is primarily utilized by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors for developing new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in fluorinated drug candidates targeting CNS disorders and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, where the fluorine and chlorine atoms enhance biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of fluorinated liquid crystal compounds and organic light-emitting diode (OLED) materials for electronic displays.
• Polymer & Resin Modifier: Acts as a functional monomer or cross-linking agent to introduce halogenated aromatic units into polymers, improving flame retardancy and chemical resistance.
• Organic Synthesis Reagent: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic aromatic substitution to introduce the methoxy-dihalo-benzene moiety into more complex structures.
• Dye & Pigment Industry: Intermediate for synthesizing specialized halogenated dyes and pigments that offer improved lightfastness and color properties.

Basic Information

Product Name	5-Chloro-2-Fluoroanisole
CAS No.	1092349-89-7
Molecular Formula	C7H6ClFO
Molecular Weight	160.57 g/mol
Synonyms	1-Chloro-4-fluoro-2-methoxybenzene; 2-Fluoro-5-chloroanisole; 4-Fluoro-2-methoxy-1-chlorobenzene; 5-Chloro-2-fluoro-1-methoxybenzene; Benzene, 1-chloro-4-fluoro-2-methoxy-; 2-Methoxy-4-fluorochlorobenzene
EINECS	Contact for details

Quality Control

Our 5-Chloro-2-Fluoroanisole is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to confirm identity and purity while monitoring for specified impurities. A Certificate of Analysis (COA) detailing all test results is provided with every shipment. We support custom synthesis and can tailor specifications to meet specific project requirements, including compliance with cGMP standards for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong oxidizing agents, strong bases, and heat sources. The compound is light-sensitive; prolonged exposure to light should be avoided.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC/HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%
Refractive Index	Contact for details
Density	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.