Description

(1R,2R)-2-(Diphenylphosphino)-2,3-Dihydro-1H-Inden-1-Amine, Min. 97% (10Wt% In Thf) is a high-purity, chiral phosphine-amine ligand, a critical component in advanced asymmetric catalysis. This compound matters because it enables highly selective and efficient chemical transformations, essential for producing enantiomerically pure pharmaceuticals and fine chemicals. It is primarily needed by research and development chemists and process engineers in the pharmaceutical, agrochemical, and specialty chemical industries for developing novel synthetic routes and optimizing manufacturing processes.

Application

• Asymmetric Hydrogenation: A key chiral ligand for the enantioselective reduction of prochiral olefins, ketones, and imines in pharmaceutical intermediate synthesis.
• Cross-Coupling Reactions: Used in palladium-catalyzed reactions such as Suzuki-Miyaura and Buchwald-Hartwig amination for C-C and C-N bond formation.
• Asymmetric Allylic Substitution: Facilitates the creation of chiral centers in complex molecule construction.
• Pharmaceutical Intermediate Synthesis: Critical for the production of active pharmaceutical ingredients (APIs) requiring high enantiomeric purity.
• Agrochemical Manufacturing: Employed in the synthesis of chiral herbicides, fungicides, and pesticides.
• Academic & Industrial R&D: A valuable tool for methodology development and exploring new catalytic systems in chemical research.
• Fine Chemical Production: Used in the manufacture of specialty flavors, fragrances, and advanced materials.

Basic Information

Product Name	(1R,2R)-2-(Diphenylphosphino)-2,3-Dihydro-1H-Inden-1-Amine, Min. 97% (10Wt% In Thf)
CAS No.	1091606-70-0
Molecular Formula	C21H20NP
Molecular Weight	317.36 g/mol
Synonyms	(1R,2R)-(-)-1-Amino-2-(diphenylphosphino)indane; (1R,2R)-1-Amino-2-(diphenylphosphino)indane; (R,R)-1-Amino-2-(diphenylphosphino)indane; (R,R)-Amphos; (1R,2R)-2-(Diphenylphosphanyl)-2,3-dihydro-1H-inden-1-amine; (1R,2R)-2-(Diphenylphosphino)-1-aminoindane; Chiral Indane-Based Phosphine-Amine Ligand
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Every batch is analyzed to confirm identity, purity, and chiral integrity. Certificates of Analysis (COA) detailing specific results for assay, enantiomeric excess, and solvent content are available upon request. We adhere to strict internal quality protocols suitable for R&D and process development applications.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C due to its sensitivity to oxidation and high volatility. The product is supplied as a solution in tetrahydrofuran (THF), which is highly flammable; keep away from heat, sparks, and open flames. Use appropriate ventilation and chemical handling procedures.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow solution
Identification (IR)	Conforms to structure
Assay (HPLC)	Min. 97.0%
Enantiomeric Excess (ee) (Chiral HPLC)	Min. 99.0%
Solvent Content (THF)	90.0 ± 1.0 wt%
Water Content (Karl Fischer)	Max. 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.