Description

(1S,2S)-2-(Diphenylphosphino)-2,3-Dihydro-1H-Inden-1-Amine, Min. 97% (10Wt% In Thf) is a high-purity, chiral phosphine-amine ligand, a critical component in asymmetric catalysis. This compound matters because it enables precise stereochemical control in the synthesis of complex pharmaceutical intermediates and fine chemicals, directly impacting yield and product purity. It is essential for R&D chemists and process engineers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-performance catalysts for challenging synthetic transformations. CAS No. 1091606-69-7.

Application

• Asymmetric Hydrogenation: A key ligand for the enantioselective reduction of prochiral olefins, ketones, and imines in API synthesis.
• Cross-Coupling Catalysis: Used in palladium-catalyzed reactions such as Suzuki-Miyaura and Buchwald-Hartwig amination for C-C and C-N bond formation.
• Pharmaceutical Intermediate Manufacturing: Facilitates the production of chiral building blocks for active pharmaceutical ingredients (APIs) with high enantiomeric excess.
• Agrochemical Synthesis: Employed in the creation of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Academic & Industrial R&D: A valuable tool for methodology development and exploring new catalytic cycles in organic synthesis.
• Fine Chemical Production: Enables the scalable, stereoselective synthesis of flavors, fragrances, and specialty materials.

Basic Information

Product Name	(1S,2S)-2-(Diphenylphosphino)-2,3-Dihydro-1H-Inden-1-Amine, Min. 97% (10Wt% In Thf)
CAS No.	1091606-69-7
Molecular Formula	C21H20NP
Molecular Weight	317.36 g/mol
Synonyms	(1S,2S)-(-)-1-Amino-2-(diphenylphosphino)indane; (1S,2S)-1-Amino-2-(diphenylphosphino)indane; (S,S)-1-Amino-2-(diphenylphosphino)indane; (S,S)-Amphos; (S,S)-Indane-Amphos; (1S,2S)-2-(Diphenylphosphanyl)-2,3-dihydro-1H-inden-1-amine; (1S,2S)-1-Amino-2,3-dihydro-2-(diphenylphosphino)-1H-indene; Chiral P,N-ligand
EINECS	Contact for details

Quality Control

Every batch of our (1S,2S)-2-(Diphenylphosphino)-2,3-Dihydro-1H-Inden-1-Amine is produced and tested under strict quality management protocols. We ensure compliance with relevant industry standards for chiral ligands and catalysts used in GMP environments. Comprehensive analytical testing, including chiral HPLC, NMR, and elemental analysis, is performed to verify identity, purity, and enantiomeric excess. Certificates of Analysis (COA) with full batch traceability are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C. The product is supplied as a 10 wt% solution in tetrahydrofuran (THF), which is highly flammable; keep away from heat, sparks, and open flame. Allow the sealed container to reach room temperature before opening to minimize moisture ingress and pressure change.

Specification

Item	Specification
Appearance (Visual)	Colorless to pale yellow solution
Identification (NMR)	Conforms to structure
Assay (HPLC)	Min. 97.0%
Enantiomeric Excess (Chiral HPLC)	Min. 99.0% ee
Solvent Content (GC)	THF: 90 ± 2 wt%
Water Content (Karl Fischer)	Max. 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.