Description

tert-Butyl 3-Aminocyclobutylcarbamate is a high-purity, protected amine derivative featuring a cyclobutane ring, a key structural motif in modern medicinal chemistry. This compound serves as a versatile and critical pharmaceutical intermediate for the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of small molecule therapeutics, particularly for central nervous system (CNS) and oncology targets.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, especially in medicinal chemistry research and development.
• Proteolysis Targeting Chimera (PROTAC) Synthesis: Used in the construction of linkers and warhead components for targeted protein degradation platforms.
• Peptidomimetic Chemistry: Incorporates the constrained cyclobutylamine structure into peptide backbones to enhance metabolic stability and bioavailability.
• Chemical Biology Probes: Serves as a precursor for labeled compounds used in target identification and validation studies.
• Agrochemical Research: Potential intermediate in the development of new crop protection agents with novel modes of action.
• Material Science: Can be used as a monomer or cross-linking agent in the synthesis of specialty polymers with unique thermal and mechanical properties.

Basic Information

Product Name	tert-Butyl 3-Aminocyclobutylcarbamate
CAS No.	1090904-48-5
Molecular Formula	C9H18N2O2
Molecular Weight	186.25 g/mol
Synonyms	3-((tert-Butoxycarbonyl)amino)cyclobutanamine; tert-Butyl N-(3-aminocyclobutyl)carbamate; 3-Aminocyclobutanamine, N-BOC-protected; BOC-3-Aminocyclobutylamine; 1-N-Boc-3-aminocyclobutane; (3-Aminocyclobutyl)carbamic acid tert-butyl ester; Cyclobutanamine, 3-[[(1,1-dimethylethoxy)carbonyl]amino]-
EINECS	Contact for details

Quality Control

Our tert-Butyl 3-Aminocyclobutylcarbamate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide Certificates of Analysis (COA) with detailed specifications for trace solvents and impurities. Our quality commitment supports applications requiring GMP-grade or research-grade materials, and we can tailor specifications to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for prolonged operations to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.