Description

Valsartan-D8 CAS NO 1089736-72-0 is a high-purity, stable isotope-labeled analog of the antihypertensive drug Valsartan, where eight hydrogen atoms are replaced by deuterium. This compound is an essential internal standard for the precise and accurate quantification of Valsartan in complex biological matrices using advanced analytical techniques like LC-MS/MS. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and bioanalytical facilities engaged in pharmacokinetic studies, drug metabolism research, and clinical trial support.

Application

• Bioanalytical Method Development & Validation: Serves as a critical internal standard for developing robust LC-MS/MS methods to analyze Valsartan in plasma, serum, and urine.
• Pharmacokinetic (PK) and Pharmacodynamic (PD) Studies: Enables accurate tracking of drug concentration over time to determine absorption, distribution, metabolism, and excretion (ADME) profiles.
• Drug Metabolism Research: Used in metabolite identification and quantification studies to understand the biotransformation pathways of Valsartan.
• Clinical Trial Analysis: Ensures reliable data generation for bioequivalence and therapeutic drug monitoring studies during clinical phases.
• Quality Control in Pharmaceutical Manufacturing: Can be utilized in analytical labs for impurity profiling and assay verification of Valsartan active pharmaceutical ingredient (API) and finished dosage forms.
• Forensic and Doping Control Analysis: Applied in specialized testing laboratories for the definitive identification and quantification of Valsartan.

Basic Information

Product Name	Valsartan-D8
CAS No.	1089736-72-0
Molecular Formula	C24H21D8N5O3
Molecular Weight	443.56 g/mol
Synonyms	Deuterated Valsartan; Valsartan-d8; (S)-N-Valeryl-N-{[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl}-valine-d8; N-(1-Oxopentyl)-N-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-L-valine-d8; L-Valine, N-(1-oxopentyl)-N-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-, pentadeutero; Diovan-d8 (labeled analog); Internal Standard for Valsartan.
EINECS	Contact for details

Quality Control

Our Valsartan-D8 is manufactured under strict quality control protocols to ensure the highest standards of isotopic purity and chemical integrity, which are critical for reliable analytical results. Each batch is characterized using NMR (for deuterium incorporation) and analyzed by advanced techniques like HPLC and LC-MS for chemical and isotopic purity. A comprehensive Certificate of Analysis (COA) is provided, detailing batch-specific data including assay, isotopic enrichment, and impurity profile. Our quality system supports compliance with the rigorous demands of GLP and GMP environments.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccant in the container. Keep container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Enrichment)	≥ 98 atom % D
Chemical Purity (by NMR)	Conforms
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.