Description

1-[4-(Trifluoromethyl)Phenyl]Cyclobutanecarboxylic Acid is a high-value, multifunctional organic building block featuring a cyclobutane core substituted with a carboxylic acid and a trifluoromethylphenyl group. This compound is critical for medicinal chemistry and advanced materials research, where its unique steric and electronic properties enable the development of novel active pharmaceutical ingredients (APIs) and specialty polymers. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel drug candidates, particularly for central nervous system (CNS) and anti-inflammatory targets.
• Agrochemical Research: Used in developing advanced herbicides and pesticides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for specialty monomers used in electronic display technologies and organic light-emitting diodes.
• Polymer Modification: Incorporated as a co-monomer to impart rigidity, thermal stability, and specific solubility profiles to high-performance engineering plastics.
• Ligand Synthesis: Utilized in organometallic chemistry for creating novel chiral ligands used in asymmetric catalysis.
• Fluorine Chemistry Studies: Acts as a model compound for investigating the influence of the CF3 group on reaction kinetics and molecular conformation.

Basic Information

Product Name	1-[4-(Trifluoromethyl)Phenyl]Cyclobutanecarboxylic Acid
CAS No.	1086379-78-3
Molecular Formula	C12H11F3O2
Molecular Weight	244.21 g/mol
Synonyms	4-(Trifluoromethyl)phenylcyclobutanecarboxylic Acid; 1-[4-(Trifluoromethyl)phenyl]cyclobutanecarboxylic acid; α-(4-Trifluoromethylphenyl)cyclobutanecarboxylic Acid; Cyclobutanecarboxylic acid, 1-[4-(trifluoromethyl)phenyl]-; 1-(4-Trifluoromethylphenyl)cyclobutanecarboxylic Acid
EINECS	Contact for details

Quality Control

Our 1-[4-(Trifluoromethyl)Phenyl]Cyclobutanecarboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and KF titration for moisture content, to ensure it meets the stringent requirements for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.