Description

(±)-Metanephrine-A,,-D3 Hcl is a high-purity, deuterium-labeled internal standard used in quantitative analytical chemistry. This compound is essential for ensuring the accuracy and reliability of mass spectrometry-based assays, particularly in clinical and pharmaceutical research. It is primarily required by analytical laboratories, contract research organizations (CROs), and pharmaceutical companies engaged in method development and validation for biomarker analysis.

Application

• Internal Standard for LC-MS/MS: Critical for the precise quantification of metanephrines and related catecholamine metabolites in biological matrices like plasma and urine.
• Clinical Diagnostics: Used in the development and quality control of in-vitro diagnostic (IVD) tests for pheochromocytoma and paraganglioma.
• Biomarker Research: Enables accurate measurement of neurotransmitter metabolites in studies related to hypertension, stress, and neurological disorders.
• Pharmaceutical Analysis: Supports drug metabolism and pharmacokinetic (DMPK) studies by providing a stable isotope-labeled reference for analyte tracking.
• Forensic Toxicology: Applied in method development for the confirmatory analysis of sympathomimetic amines and their metabolites.
• Method Validation & GLP Compliance: Serves as a key component in establishing and validating analytical methods according to Good Laboratory Practice (GLP) guidelines.

Basic Information

Item	Details
Product Name	(±)-Metanephrine-A,,-D3 Hcl
CAS No.	1085333-94-3
Molecular Formula	C10H12D3NO3 • HCl
Molecular Weight	233.71 g/mol (for free base C10H12D3NO3)
Synonyms	DL-Metanephrine-d3 Hydrochloride; 3-O-Methylepinephrine-d3 HCl; 4-[1-Hydroxy-2-(methylamino)ethyl]-2-methoxyphenol-d3 Hydrochloride; Metanephrine-d3 HCl; (±)-Meta-D3 Hcl; 3-Methoxyadrenaline-d3 hydrochloride; Deuterated Metanephrine HCl; Internal Standard for Metanephrines
EINECS	Contact for details

Quality Control

Every batch of (±)-Metanephrine-A,,-D3 Hcl is manufactured and tested under strict quality systems to ensure exceptional purity and isotopic enrichment, which are critical for its performance as an internal standard. Our products undergo rigorous quality testing, including NMR and mass spectrometry, to confirm chemical structure, isotopic purity (>98 atom % D), and chemical purity. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data are provided to support your method validation and regulatory compliance.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC-MS)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity	≥ 98 atom % D
Chemical Purity	≥ 95%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.