Description

5-(2,4-Difluorophenyl)Isoxazole-3-Carboxylic Acid is a high-purity, multifunctional heterocyclic building block of significant interest in advanced organic synthesis. This compound matters because it serves as a critical precursor for developing novel active pharmaceutical ingredients (APIs) and agrochemicals, enabling the creation of molecules with enhanced biological activity and selectivity. It is primarily needed by research and development chemists, process development scientists, and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries seeking to innovate within the isoxazole chemical space.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new drug candidates, particularly in therapeutic areas requiring fluorinated heterocycles for improved metabolic stability and membrane permeability.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the difluorophenyl and isoxazole motifs contribute to efficacy and environmental profile.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of novel organic electronic materials and functional polymers.
• Chemical Biology Probes: Utilized to build molecular probes for studying enzyme function and biological pathways due to its specific structural features.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-purity fluorinated intermediates.

Basic Information

Product Name	5-(2,4-Difluorophenyl)Isoxazole-3-Carboxylic Acid
CAS No.	1083224-23-0
Molecular Formula	C10H5F2NO3
Molecular Weight	225.15 g/mol
Synonyms	5-(2,4-Difluorophenyl)-1,2-oxazole-3-carboxylic acid; 5-(2,4-Difluorophenyl)isoxazole-3-carboxylic acid; 3-Isoxazolecarboxylic acid, 5-(2,4-difluorophenyl)-; 1083224-23-0; 5-(2,4-Difluorophenyl)-3-carboxyisoxazole; DFPA; 2,4-Difluoro-5-(3-carboxyisoxazol-5-yl)benzene
EINECS	Contact for details

Quality Control

Our 5-(2,4-Difluorophenyl)Isoxazole-3-Carboxylic Acid is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency meet the high standards required for research and commercial synthesis. Certificates of Analysis (COA) with full batch traceability are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.