Description

(Z)-Ethyl 2-Benzamido-4,4-Difluorobut-2-Enoate is a high-purity, advanced pharmaceutical intermediate characterized by its unique difluorinated enoate structure. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of novel active pharmaceutical ingredients (APIs) where the introduction of fluorine atoms can dramatically alter metabolic stability and bioavailability. It is an essential building block for pharmaceutical companies, agrochemical research facilities, and advanced material scientists seeking to develop new compounds with enhanced properties.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, especially in oncology, antiviral, and central nervous system (CNS) therapeutic areas.
• Medicinal Chemistry Building Block: Used for structure-activity relationship (SAR) studies to optimize potency and pharmacokinetic profiles of lead compounds.
• Agrochemical Synthesis: Serves as a precursor in the development of novel pesticides and herbicides, leveraging the bioactivity of the benzamido and difluoro motifs.
• Chemical Biology Probe Development: Utilized in the creation of molecular probes for studying enzyme mechanisms and biological pathways.
• Material Science Research: Potential monomer or precursor for specialty polymers and advanced materials with specific electronic or surface properties.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and GMP production of client-specific molecules.

Basic Information

Product Name	(Z)-Ethyl 2-Benzamido-4,4-Difluorobut-2-Enoate
CAS No.	1083005-83-7
Molecular Formula	C₁₃H₁₃F₂NO₃
Molecular Weight	269.25 g/mol
Synonyms	Ethyl (2Z)-2-(benzoylamino)-4,4-difluorobut-2-enoate; 2-Benzamido-4,4-difluorobut-2-enoic Acid Ethyl Ester (Z-isomer); (Z)-Ethyl 2-(Benzoylamino)-4,4-difluorobut-2-enoate; 1083005-83-7; Ethyl (Z)-2-benzamido-4,4-difluorobut-2-enoate; But-2-enoic acid, 2-(benzoylamino)-4,4-difluoro-, ethyl ester, (2Z)-
EINECS	Contact for details

Quality Control

Our (Z)-Ethyl 2-Benzamido-4,4-Difluorobut-2-Enoate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring a reliable supply for research and development purposes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Isomeric Purity (Z-isomer)	≥ 99.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.