Description

n-Fmoc-(1-Benzotriazolylcarbonyl)Methylamine is a specialized, high-purity building block used in solid-phase peptide synthesis (SPPS) and other advanced organic syntheses. This compound serves as a key reagent for the efficient introduction of the Fmoc-protected methylamine moiety, enabling the controlled construction of complex molecular architectures. It is essential for research and development laboratories in the pharmaceutical, biotechnology, and fine chemical sectors focused on peptide-based drug discovery and development.

Application

• Solid-Phase Peptide Synthesis (SPPS): A critical reagent for the coupling of Fmoc-protected methylamine during automated or manual peptide chain assembly.
• Pharmaceutical Intermediate: Used in the research and development of novel therapeutic peptides and peptidomimetics.
• Bioconjugation: Facilitates the site-specific labeling or modification of peptides and proteins for diagnostic and research applications.
• Combinatorial Chemistry: Employed in the generation of diverse chemical libraries for high-throughput screening in drug discovery.
• Fine Chemical Synthesis: Acts as a versatile building block for the synthesis of complex organic molecules requiring protected amine functionality.
• Academic & Industrial R&D: Supports fundamental research in organic chemistry, medicinal chemistry, and chemical biology.

Basic Information

Product Name	n-Fmoc-(1-Benzotriazolylcarbonyl)Methylamine
CAS No.	1082989-49-8
Molecular Formula	C24H19N3O3
Molecular Weight	397.43 g/mol
Synonyms	Fmoc-NH-CH2-CO-OBt; 1-[(9H-Fluoren-9-ylmethoxy)carbonylamino]methyl 1H-benzotriazole-1-carboxylate; (Fmoc-aminomethyl) benzotriazolyl carbonate; N-[(Benzotriazol-1-yloxy)carbonylmethyl]-9-fluorenylmethoxycarboxamide; Fmoc-Aminomethyl O-Benzotriazolyl Carbonate; Fmoc-NH-CH2-OCO-OBt; Fmoc-protected aminomethyl benzotriazolyl carbonate
EINECS	Contact for details

Quality Control

Our n-Fmoc-(1-Benzotriazolylcarbonyl)Methylamine is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for sensitive synthetic applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable to support our clients in regulated research and development environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent decomposition. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.