Description

Boc-(R)-4-Trifluoromethylhomophenylalanine is a high-purity, non-natural amino acid derivative featuring a Boc-protected amine and a trifluoromethylphenyl side chain. This compound is a critical chiral building block for the synthesis of complex peptides and peptidomimetics, where its unique fluorinated aromatic group can significantly modulate biological activity, metabolic stability, and lipophilicity. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents, including protease inhibitors, GPCR ligands, and other bioactive molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for metabolic and central nervous system (CNS) diseases.
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate a fluorinated, hydrophobic amino acid residue, enhancing peptide stability and membrane permeability.
• Medicinal Chemistry & SAR Studies: Employed to explore structure-activity relationships by introducing a trifluoromethyl group, which can affect binding affinity and pharmacokinetic properties.
• Protease Inhibitor Design: Serves as a component in the design of inhibitors for various proteases, where the homophenylalanine scaffold is a common recognition element.
• Chemical Biology Probes: Incorporated into peptide-based probes for studying protein-protein interactions and enzyme mechanisms.
• Agrochemical Research: Potential use as a building block for developing novel agrochemicals with improved activity and environmental profile.

Basic Information

Product Name	Boc-(R)-4-Trifluoromethylhomophenylalanine
CAS No.	1082750-53-5
Molecular Formula	C₁₆H₂₀F₃NO₄
Molecular Weight	347.33 g/mol
Synonyms	(R)-2-((tert-Butoxycarbonyl)amino)-5-(4-(trifluoromethyl)phenyl)pentanoic acid; N-(tert-Butoxycarbonyl)-4-(trifluoromethyl)-D-homophenylalanine; Boc-D-4-CF3-homoPhe-OH; Boc-(R)-4-CF3-homoPhe; Boc-4-Trifluoromethyl-D-homophenylalanine; tert-Butyl (R)-(4-(4-(trifluoromethyl)phenyl)-1-carboxybutyl)carbamate; N-Boc-4-trifluoromethyl-D-homophenylalanine
EINECS	Contact for details

Quality Control

Our Boc-(R)-4-Trifluoromethylhomophenylalanine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC to ensure enantiomeric purity and identity confirmation by NMR and mass spectrometry. We provide a detailed Certificate of Analysis (COA) with every shipment, which includes data for purity, chiral purity, and residual solvent content, meeting the stringent requirements of pharmaceutical R&D.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.