Description

2-(2-Cyclopropoxy-5-Fluorophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is a high-value organoboron building block, specifically a pinacol boronic ester, critical for modern synthetic chemistry. Its core value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex biaryl and heterobiaryl structures. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it serves as a key intermediate in the development of new active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A crucial building block for synthesizing novel drug candidates, particularly in the development of kinase inhibitors, antiviral agents, and central nervous system (CNS) active compounds.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides that require specific fluorinated biaryl motifs for enhanced activity and selectivity.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as polymers and small molecules for OLEDs (Organic Light-Emitting Diodes) and OFETs (Organic Field-Effect Transistors).
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands and catalysts used in asymmetric synthesis and other transition metal-catalyzed processes.
• Chemical Biology Probes: Utilized to create labeled compounds and molecular probes for studying biological pathways and target engagement.
• Custom Synthesis and Contract Manufacturing: A key reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	2-(2-Cyclopropoxy-5-Fluorophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	1079402-44-0
Molecular Formula	C₁₇H₂₄BFO₃
Molecular Weight	306.18 g/mol
Synonyms	5-Fluoro-2-(cyclopropoxy)benzeneboronic acid pinacol ester; 2-(5-Fluoro-2-(cyclopropoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; (5-Fluoro-2-(cyclopropoxy)phenyl)boronic acid pinacol ester; 2-Cyclopropoxy-5-fluorophenylboronic acid pinacol ester; Boronic acid, B-[5-fluoro-2-(cyclopropoxy)phenyl]-, 1,1-dimethylethyl ester (9CI); 1079402-44-0; Contact for details on additional trade names.
EINECS	Contact for details

Quality Control

Our 2-(2-Cyclopropoxy-5-Fluorophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. All products undergo rigorous analytical testing, including HPLC, NMR (¹H, ¹³C, ¹⁹F, ¹¹B), and GC-MS, to confirm identity, purity, and the absence of critical impurities. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and when dispensing to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Typical 98-99%)
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.