Description

4,4,5,5-Tetramethyl-2-[2-(2,2,2-Trifluoroethyl)Phenyl]-1,3,2-Dioxaborolane is a high-purity, advanced boronic ester building block essential for modern synthetic chemistry. Its value lies in enabling precise carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone for constructing complex molecular architectures. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for creating novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate Synthesis: A key reagent for constructing biaryl and heterobiaryl scaffolds present in numerous drug candidates, particularly in oncology and CNS therapeutic areas.
• Agrochemical Research & Development: Used to synthesize novel herbicides, fungicides, and insecticides by introducing the trifluoroethylphenyl moiety into active molecules.
• Organic Light-Emitting Diode (OLED) Materials: Serves as a precursor for electron-transport or host materials in display and lighting technologies.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands for transition metal catalysis and organocatalysis.
• Polymer and Advanced Material Science: Facilitates the synthesis of monomers and functional polymers with tailored electronic or physical properties.
• Academic and Contract Research: A vital tool for methodological development and exploring new chemical spaces in academic laboratories and CROs.

Basic Information

Item	Detail
Product Name	4,4,5,5-Tetramethyl-2-[2-(2,2,2-Trifluoroethyl)Phenyl]-1,3,2-Dioxaborolane
CAS No.	1079402-24-6
Molecular Formula	C14H18BF3O2
Molecular Weight	286.10 g/mol
Synonyms	2-(2-(2,2,2-Trifluoroethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; [2-(2,2,2-Trifluoroethyl)phenyl]boronic acid pinacol ester; 2-(2-(Trifluoroethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; (2-(2,2,2-Trifluoroethyl)phenyl)boronic acid pinacol ester; 1,3,2-Dioxaborolane, 4,4,5,5-tetramethyl-2-[2-(2,2,2-trifluoroethyl)phenyl]-; Trifluoroethylphenylboronic acid pinacol ester; 2-(2-Trifluoroethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
EINECS	Contact for details

Quality Control

Every batch of 4,4,5,5-Tetramethyl-2-[2-(2,2,2-Trifluoroethyl)Phenyl]-1,3,2-Dioxaborolane is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure high purity and batch-to-batch consistency. Our standard quality commitment includes comprehensive analysis via NMR, HPLC, and GC to verify identity, purity, and impurity profiles. Certificates of Analysis (COA) detailing all specifications are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and to maintain optimal purity during use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0% (Area %)
Purity (GC)	≥96.0%
Water Content (KF)	≤0.5% w/w

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.