Description

Quetiapine n-Oxide is a key pharmaceutical intermediate and metabolite of the atypical antipsychotic drug Quetiapine. This compound is of significant importance for research and development in neuropharmacology and for ensuring drug safety and efficacy profiles. It is primarily utilized by pharmaceutical manufacturers and analytical laboratories for impurity profiling, metabolic studies, and the synthesis of high-purity active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Critical for the synthesis and scale-up production of Quetiapine and related compounds.
• Reference Standard: Serves as a certified reference material (CRM) for analytical method development and validation in quality control laboratories.
• Metabolite Studies: Used in preclinical and clinical research to understand the metabolic pathways and pharmacokinetics of Quetiapine.
• Impurity Profiling: Essential for identifying and quantifying oxidative degradation products in drug substance and finished product stability studies.
• Bioanalytical Research: Employed in the development of assays for drug monitoring in biological matrices such as plasma and serum.
• Process Chemistry: Acts as a starting material or intermediate in the development of novel synthetic routes and process optimization.

Basic Information

Product Name	Quetiapine n-Oxide
CAS No.	1076199-40-0
Molecular Formula	C21H25N3O3S
Molecular Weight	399.51 g/mol
Synonyms	2-[2-(4-Dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]ethanol N-Oxide; Quetiapine N-Oxide; Quetiapine Metabolite (N-Oxide); 11-[4-[2-(2-Hydroxyethoxy)ethyl]-1-piperazinyl]dibenzo[b,f][1,4]thiazepine 5-Oxide; UNII-0F8V22M01E; DBZP N-Oxide; ICI 204,636 N-Oxide
EINECS	Contact for details

Quality Control

Our Quetiapine n-Oxide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent control of residual solvents and heavy metals. Certificates of Analysis (COA) detailing all specifications are provided to ensure compliance with pharmaceutical research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Maximum Unknown Impurity	≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.