Description

4-Fluorohydroxy Bupropion is a fluorinated derivative and a key metabolite of the pharmaceutical compound bupropion. This compound is of significant interest in pharmaceutical research and development, particularly for metabolic studies and the synthesis of novel active pharmaceutical ingredients (APIs). It serves as a crucial reference standard and advanced intermediate for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors.

Application

• Pharmaceutical Reference Standard: Used for analytical method development, validation, and quality control in drug testing laboratories.
• Metabolite Research: Critical for studying the metabolic pathways, pharmacokinetics, and pharmacodynamics of bupropion and related compounds.
• Advanced Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel fluorinated drug candidates and analogs.
• Biochemical Research: Employed in in-vitro and in-vivo studies to investigate biological activity and mechanism of action.
• Analytical Chemistry: Used as a high-purity calibrant in chromatographic (HPLC, LC-MS) and spectroscopic analyses.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and development services.

Basic Information

Product Name	4-Fluorohydroxy Bupropion
CAS No.	1076198-13-4
Molecular Formula	C13H18FNO2
Molecular Weight	239.29 g/mol
Synonyms	4-Fluorohydroxybupropion; 2-(tert-Butylamino)-1-(4-fluoro-3-hydroxyphenyl)propan-1-one; (RS)-2-(tert-Butylamino)-1-(4-fluoro-3-hydroxyphenyl)propan-1-one; 1-Propanone, 2-[(1,1-dimethylethyl)amino]-1-(4-fluoro-3-hydroxyphenyl)-, (±)-; Bupropion 4-Fluoro-3-hydroxy Metabolite; Hydroxy-4-fluoro Bupropion; BW 306U metabolite
EINECS	Contact for details

Quality Control

Our 4-Fluorohydroxy Bupropion is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data, including HPLC purity, NMR, and MS confirmation. Our quality commitment aligns with the standards expected for pharmaceutical reference materials and advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.