Description

L-Erythro-Ritalinic Acid CAS NO 1076192-92-1 is a high-purity chiral intermediate of significant importance in the synthesis of active pharmaceutical ingredients (APIs). Its primary value lies in its role as a key building block for the production of central nervous system stimulants, most notably methylphenidate. This compound is essential for pharmaceutical R&D laboratories, fine chemical manufacturers, and contract development and manufacturing organizations (CDMOs) engaged in the development of enantiomerically pure therapeutics.

Application

• Pharmaceutical Intermediate: Critical chiral precursor in the synthesis of enantiomerically pure methylphenidate (Ritalin®) and related analogs.
• Active Pharmaceutical Ingredient (API) Development: Serves as a key building block for research and scale-up of novel CNS-targeting drug candidates.
• Reference Standard: Used as a high-purity analytical standard in quality control and method development for pharmacokinetic and metabolic studies.
• Metabolite Studies: Employed in research to study the pharmacokinetics, pharmacodynamics, and metabolic pathways of psychostimulant medications.
• Asymmetric Synthesis: Valuable chiral synthon for organic chemists developing new asymmetric catalytic routes or methodologies.
• Regulatory Submissions: Provides a characterized starting material for Drug Master Files (DMFs) and regulatory documentation.

Basic Information

Product Name	L-Erythro-Ritalinic Acid
CAS No.	1076192-92-1
Molecular Formula	C14H19NO2
Molecular Weight	233.31 g/mol
Synonyms	(2R,2'R)-2-Phenyl-2-(2-piperidin-2-ylacetoxy)acetic acid; (R,R)-Methylphenidate Acid; L-threo-Methylphenidate Acid (obsolete); d-threo-Methylphenidate Acid (obsolete); Ritalinic Acid, L-Erythro isomer; α-Phenyl-2-piperidineacetic acid, (R,R)-; L-Erythro-Methylphenidate Acid; Dexmethylphenidate Acid
EINECS	Contact for details

Quality Control

Our L-Erythro-Ritalinic Acid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for pharmaceutical applications. Each lot undergoes comprehensive analytical testing, including chiral purity determination, to confirm identity, potency, and impurity profiles. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment. We support compliance with cGMP, ICH Q7, and relevant pharmacopeial guidelines as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% (L-Erythro isomer)
Related Substances (HPLC)	Total impurities ≤2.0%
Residual Solvents (GC)	Complies with ICH Q3C
Loss on Drying	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.