Description

Atracurium Impurity V is a specified impurity of the neuromuscular blocking agent Atracurium besylate, identified by the CAS number 1075726-86-1. This compound is critical for pharmaceutical research and development, serving as a key reference standard in the analytical characterization and quality control of Atracurium drug substances and products. It is primarily required by pharmaceutical manufacturers, analytical laboratories, and regulatory bodies to ensure drug purity, safety, and compliance with stringent pharmacopeial standards.

Application

• Primary use as a pharmaceutical reference standard for the identification and quantification of Atracurium Impurity V.
• Critical component in analytical method development and validation (HPLC, LC-MS) for Atracurium besylate.
• Essential for impurity profiling and stability studies of Atracurium drug substances and finished products.
• Used in regulatory compliance and submission to agencies like the FDA and EMA.
• Supports quality control (QC) and quality assurance (QA) processes in GMP manufacturing environments.
• Valuable for pharmacological and toxicological research related to Atracurium degradation pathways.

Basic Information

Product Name	Atracurium Impurity V
CAS No.	1075726-86-1
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Atracurium Related Compound V; Laudanosine N-oxide; 1-(3,4-Dimethoxyphenyl)methyl-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-2-ium; Atracurium Degradant; Atracurium Besylate Impurity V; 2-Methyl-1-(3,4,5-trimethoxybenzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-2-ium (common structural descriptor)
EINECS	Contact for details

Quality Control

Every batch of Atracurium Impurity V is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our quality system is designed to meet the exacting standards of pharmaceutical impurity supply, with testing typically including HPLC for assay and related substances, along with spectroscopic confirmation. A comprehensive Certificate of Analysis (COA) detailing all test results and specifications is provided with each shipment to support your regulatory and research needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.